Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1933-1940, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lang, C. C.
Right arrow Articles by Wilson, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lang, C. C.
Right arrow Articles by Wilson, J. R.

Vol. 83, Issue 6, 1933-1940, December 1997

Prostaglandin production contributes to exercise-induced vasodilation in heart failure

Chim C. Lang, Don B. Chomsky, Javed Butler, Shiv Kapoor, and John R. Wilson

Division of Cardiology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6300; and Clinical Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Received 20 March 1997; accepted in final form 4 August 1997.

Lang, Chim C., Don B. Chomsky, Javed Butler, Shiv Kapoor, and John R. Wilson. Prostaglandin production contributes to exercise-induced vasodilation in heart failure. J. Appl. Physiol. 83(6): 1933-1940, 1997.---Endothelial release of prostaglandins may contribute to exercise-induced skeletal muscle arteriolar vasodilation in patients with heart failure. To test this hypothesis, we examined the effect of indomethacin on leg circulation and metabolism in eight chronic heart failure patients, aged 55 ± 4 yr. Central hemodynamics and leg blood flow, determined by thermodilution, and leg metabolic parameters were measured during maximum treadmill exercise before and 2 h after oral administration of indomethacin (75 mg). Leg release of 6-ketoprostaglandin F1alpha was also measured. During control exercise, leg blood flow increased from 0.34 ± 0.03 to 1.99 ± 0.19 l/min (P < 0.001), leg O2 consumption from 13.6 ± 1.8 to 164.5 ± 16.2 ml/min (P < 0.001), and leg prostanoid release from 54.1 ± 8.5 to 267.4 ± 35.8 pg/min (P < 0.001). Indomethacin suppressed release of prostaglandin F1alpha (P < 0.001) throughout exercise and decreased leg blood flow during exercise (P < 0.05). This was associated with a corresponding decrease in leg O2 consumption (P < 0.05) and a higher level of femoral venous lactate at peak exercise (P < 0.01). These data suggest that release of vasodilatory prostaglandins contributes to skeletal muscle arteriolar vasodilation in patients with heart failure.

congestive heart failure; indomethacin; regional blood flow

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Momen, J. Cui, P. McQuillan, and L. I. Sinoway
Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans
Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2184 - H2190.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
W. G. Schrage, J. H. Eisenach, and M. J. Joyner
Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans
J. Physiol., February 15, 2007; 579(1): 227 - 236.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
A. C. Scott, R. Wensel, C. H. Davos, P. Georgiadou, L. Ceri Davies, A. J.S. Coats, D. P. Francis, and M. F. Piepoli
Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure
Eur. Heart J., October 2, 2004; 25(20): 1806 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
W. G. Schrage, M. J. Joyner, and F. A. Dinenno
Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans
J. Physiol., June 1, 2004; 557(2): 599 - 611.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. C. Scott, R. Wensel, C. H. Davos, M. Kemp, A. Kaczmarek, J. Hooper, A. J.S. Coats, and M. F. Piepoli
Chemical Mediators of the Muscle Ergoreflex in Chronic Heart Failure: A Putative Role for Prostaglandins in Reflex Ventilatory Control
Circulation, July 9, 2002; 106(2): 214 - 220.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Varin, P. Mulder, F. Tamion, V. Richard, J.-P. Henry, F. Lallemand, G. Lerebours, and C. Thuillez
Improvement of Endothelial Function by Chronic Angiotensin-Converting Enzyme Inhibition in Heart Failure : Role of Nitric Oxide, Prostanoids, Oxidant Stress, and Bradykinin
Circulation, July 18, 2000; 102(3): 351 - 356.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Benoit, M. Jordan, H. Wagner, and P. D. Wagner
Effect of NO, vasodilator prostaglandins, and adenosine on skeletal muscle angiogenic growth factor gene expression
J Appl Physiol, May 1, 1999; 86(5): 1513 - 1518.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Duffy, G. New, B. T. Tran, R. W. Harper, and I. T. Meredith
Relative contribution of vasodilator prostanoids and NO to metabolic vasodilation in the human forearm
Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H663 - H670.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online