Journal of Applied Physiology
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J Appl Physiol 83: 1917-1922, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 6, 1917-1922, December 1997

Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise

C. Adrian Hutber, B. B. Rasmussen, and W. W. Winder

Zoology Department, Brigham Young University, Provo, Utah 84602

Received 14 May 1997; accepted in final form 22 July 1997.

Hutber, C. Adrian, B. B. Rasmussen, and W. W. Winder. Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise. J. Appl. Physiol. 83(6): 1917-1922, 1997.---Muscle malonyl-CoA has been postulated to regulate fatty acid metabolism by inhibiting carnitine palmitoyltransferase 1. In nontrained rats, malonyl-CoA decreases in working muscle during exercise. Endurance training is known to increase a muscle's reliance on fatty acids as a substrate. This study was designed to investigate whether the decline in malonyl-CoA with exercise would be greater in trained than in nontrained muscle, thereby allowing increased fatty acid oxidation. After 6-10 wk of endurance training (2 h/day) or treadmill habituation (5-10 min/day), rats were killed at rest or after running up a 15% grade at 21 m/min for 5, 20, or 60 min. Training attenuated the exercise-induced drop in malonyl-CoA and prevented the exercise-induced increase in the constant for citrate activation of acetyl-CoA carboxylase in the red quadriceps muscle of rats run for 20 and 60 min. Hence, contrary to expectations, the decrease in malonyl-CoA was less in trained than in nontrained muscle during a single bout of prolonged submaximal exercise.

muscle acetyl-CoA carboxylase; carnitine palmitoyltransferase; fatty acid oxidation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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