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Vol. 83, Issue 6, 1900-1906, December 1997
Section of Applied Physiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
Received 18 November 1996; accepted in final form 23 July 1997.
Mier, Constance M., Michael J. Turner, Ali A. Ehsani, and
Robert J. Spina. Cardiovascular adaptations to 10 days of cycle
exercise. J. Appl. Physiol. 83(6):
1900-1906, 1997.
We hypothesized that 10 days of training would
enhance cardiac output (CO) and stroke volume (SV) during peak exercise
and increase the inotropic response to 
-adrenergic stimulation. Ten
subjects [age 26 ± 2 (SE) yr] trained on a cycle
ergometer for 10 days. At peak exercise, training increased
O2 uptake, CO, and SV
(P < 0.001). Left ventricular (LV)
size and function at rest were assessed with two-dimensional echocardiography before (baseline) and after atropine injection (1.0 mg) and during four graded doses of dobutamine. LV end-diastolic diameter increased with training (P < 0.02), whereas LV wall thickness was unchanged. LV contractile
performance was assessed by relating fractional shortening (FS) to the
estimated end-systolic wall stress
(
ES). Training increased the
slope of the FS-ES relationship (P < 0.05), indicating enhanced
systolic function. The increase in slope correlated with increases in
CO (r = 
0.71,
P < 0.05) and SV
(r = 0.70,
P < 0.05). The increase in blood
volume also correlated with increases in CO
(r = 0.80, P < 0.01) and SV (r = 0.85, P < 0.004). These data
show that 10 days of training enhance the inotropic response to
-adrenergic stimulation, associated with increases in CO and SV
during peak exercise.
short-term training; left ventricular function; cardiac output; stroke volume
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