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Vol. 83, Issue 6, 1890-1899, December 1997
Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284-7764
Received 10 February 1997; accepted in final form 21 July 1997.
Mifflin, Steven W. Intensity and frequency dependence
of laryngeal afferent inputs to respiratory hypoglossal motoneurons. J. Appl. Physiol. 83(6):
1890-1899, 1997.
Inspiratory hypoglossal motoneurons (IHMs)
mediate contraction of the genioglossus muscle and contribute to the
regulation of upper airway patency. Intracellular recordings were
obtained from antidromically identified IHMs in anesthetized,
vagotomized cats, and IHM responses to electrical activation of
superior laryngeal nerve (SLN) afferent fibers at various frequencies
and intensities were examined. SLN stimulus frequencies <2 Hz evoked
an excitatory-inhibitory postsynaptic potential (EPSP-IPSP) sequence or
only an IPSP in most IHMs that did not change in amplitude as the
stimulus was maintained. During sustained stimulus frequencies of
5-10 Hz, there was a reduction in the amplitude of SLN-evoked
IPSPs with time with variable changes in the EPSP. At stimulus
frequencies >25 Hz, the amplitude of EPSPs and IPSPs was reduced over
time. At a given stimulus frequency, increasing stimulus intensity
enhanced the decay of the SLN-evoked postsynaptic potentials (PSPs).
Frequency-dependent attenuation of SLN inputs to IHMs also occurred in
newborn kittens. These results suggest that activation of SLN afferents
evokes different PSP responses in IHMs depending on the stimulus
frequency. At intermediate frequencies, inhibitory inputs are
selectively filtered so that excitatory inputs predominate. At higher
frequencies there was no discernible SLN-evoked PSP temporally locked
to the SLN stimuli. Alterations in SLN-evoked PSPs could play a role in
the coordination of genioglossal contraction during respiration,
swallowing, and other complex motor acts where laryngeal afferents are
activated.
upper airway patency; control of breathing; neonatal respiration; airway-maintaining muscles and reflexes
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