Journal of Applied Physiology
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J Appl Physiol 83: 1849-1856, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 6, 1849-1856, December 1997

Effects of surfactant proteins SP-B and SP-C on dynamic and static mechanics of immature lungs

Tsutomu Kobayashi, Katsumi Tashiro, Ken Yamamoto, Shunichi Nitta, Shigeo Ohmura, and Yasuhiro Suzuki

Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa 920; and Department of Molecular Pathology, Chest Disease Research Institute, Kyoto University, Kyoto 606, Japan

Received 10 March 1997; accepted in final form 28 July 1997.

Kobayashi, Tsutomu, Katsumi Tashiro, Ken Yamamoto, Shunichi Nitta, Shigeo Ohmura, and Yasuhiro Suzuki. Effects of surfactant proteins SP-B and SP-C on dynamic and static mechanics of immature lungs. J. Appl. Physiol. 83(6): 1849-1856, 1997.---To investigate the effects of surfactant proteins B (SP-B) and C (SP-C) on lung mechanics, we compared tidal and static lung volumes of immature rabbits anesthetized with pentobarbital sodium and given reconstituted test surfactants (RTS). With a series of RTS having various SP-B concentrations (0-0.7%) but a fixed SP-C concentration (1.4%), both the tidal volume with 25-cmH2O insufflation pressure and the static volume deflated to 5-cmH2O airway pressure increased, significantly correlating with the SP-B concentration: the former increased from 6.5 to 26.0 ml/kg (mean), and the latter increased from 6.4 to 31.8 ml/kg. With another series of RTS having a fixed SP-B concentration (0.7%) but various SP-C concentrations (0-1.4%), the tidal volume increased from 5.1 to 24.8 ml/kg, significantly correlating with the SP-C concentration, whereas the static volume increased from 3.4 to 32.0 ml/kg, the ceiling value, in the presence of a minimal concentration of SP-C (0.18%). In conclusion, certain doses of SP-B and SP-C were indispensable for optimizing dynamic lung mechanics; the static mechanics, however, required significantly less SP-C.

lung volume; newborn rabbit; surface adsorption; tidal volume; ventilation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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