Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1814-1821, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wiggs, B. R.
Right arrow Articles by Kamm, R. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wiggs, B. R.
Right arrow Articles by Kamm, R. D.

Vol. 83, Issue 6, 1814-1821, December 1997

On the mechanism of mucosal folding in normal and asthmatic airways

Barry R. Wiggs1, Constantine A. Hrousis1, Jeffrey M. Drazen2, and Roger D. Kamm1

1 Center for Biomedical Engineering and the Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139; and 2 Division of Respiratory and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115

Received 30 July 1996; accepted in final form 1 August 1997.

Wiggs, Barry R., Constantine A. Hrousis, Jeffrey M. Drazen, and Roger D. Kamm. On the mechanism of mucosal folding in normal and asthmatic airways. J. Appl. Physiol. 83(6): 1814-1821, 1997.---Previous studies have demonstrated that the airway wall in asthma and chronic obstructive pulmonary disease is markedly thickened. It has also been observed that when the smooth muscle constricts the mucosa buckles, forming folds that penetrate into the airway lumen. This folding pattern may influence the amount of luminal obstruction associated with smooth muscle activation. A finite-element analysis of a two-layer composite model for an airway is used to investigate the factors that determine the mucosal folding pattern and how it is altered as a result of changes in the thickness or stiffness of the different layers that comprise the airway wall. Results demonstrate that the most critical physical characteristic is the thickness of the thin inner layer of the model. Thickening of this inner layer likely is represented by the enhanced subepithelial collagen deposition seen in asthma. Other findings show a high shear stress at or near the epithelial layer, which may explain the pronounced epithelial sloughing that occurs in asthma, and steep gradients in pressure that could cause significant shifts of liquid between wall compartments or between the wall and luminal or vascular spaces.

asthma; epithelium; mechanics; finite-element analysis; remodeling; computational model

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Cojocaru, C. G. Irvin, H. C. Haverkamp, and J. H. T. Bates
Computational assessment of airway wall stiffness in vivo in allergically inflamed mouse models of asthma
J Appl Physiol, June 1, 2008; 104(6): 1601 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Ito, H. Kume, K. Naruse, M. Kondo, N. Takeda, S. Iwata, Y. Hasegawa, and M. Sokabe
A Novel Ca2+ Influx Pathway Activated by Mechanical Stretch in Human Airway Smooth Muscle Cells
Am. J. Respir. Cell Mol. Biol., April 1, 2008; 38(4): 407 - 413.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. A. Tomei, M. M. Choe, and M. A. Swartz
Effects of dynamic compression on lentiviral transduction in an in vitro airway wall model
Am J Physiol Lung Cell Mol Physiol, January 1, 2008; 294(1): L79 - L86.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. L. James and S. Wenzel
Clinical relevance of airway remodelling in airway diseases
Eur. Respir. J., July 1, 2007; 30(1): 134 - 155.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. M. Lloyd and D. S. Robinson
Allergen-induced airway remodelling
Eur. Respir. J., May 1, 2007; 29(5): 1020 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L. Pini, Q. Hamid, J. Shannon, L. Lemelin, R. Olivenstein, P. Ernst, C. Lemiere, J. G. Martin, and M. S. Ludwig
Differences in proteoglycan deposition in the airways of moderate and severe asthmatics
Eur. Respir. J., January 1, 2007; 29(1): 71 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. K. Chu, J. Cheng, J. S. Foley, B. H. Mecham, C. A. Owen, K. J. Haley, T. J. Mariani, I. S. Kohane, D. J. Tschumperlin, and J. M. Drazen
Induction of the Plasminogen Activator System by Mechanical Stimulation of Human Bronchial Epithelial Cells
Am. J. Respir. Cell Mol. Biol., December 1, 2006; 35(6): 628 - 638.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. M. Choe, P. H. S. Sporn, and M. A. Swartz
Extracellular Matrix Remodeling by Dynamic Strain in a Three-Dimensional Tissue-Engineered Human Airway Wall Model
Am. J. Respir. Cell Mol. Biol., September 1, 2006; 35(3): 306 - 313.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
C. Boxall, S. T. Holgate, and D. E. Davies
The contribution of transforming growth factor-{beta} and epidermal growth factor signalling to airway remodelling in chronic asthma
Eur. Respir. J., January 1, 2006; 27(1): 208 - 229.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. J. Gunst
Does airway inflation stretch the bronchial mucosal membrane?
J Appl Physiol, December 1, 2005; 99(6): 2059 - 2060.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. B. Noble, A. Sharma, P. K. McFawn, and H. W. Mitchell
Elastic properties of the bronchial mucosa: epithelial unfolding and stretch in response to airway inflation
J Appl Physiol, December 1, 2005; 99(6): 2061 - 2066.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. Savla, L. E. Olson, and C. M. Waters
Mathematical modeling of airway epithelial wound closure during cyclic mechanical strain
J Appl Physiol, February 1, 2004; 96(2): 566 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. D. Pare
Airway Hyperresponsiveness in Asthma: Geometry Is Not Everything!
Am. J. Respir. Crit. Care Med., October 15, 2003; 168(8): 913 - 914.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Brusasco and R. Pellegrino
Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness
J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. M. Choe, P. H. S. Sporn, and M. A. Swartz
An in vitro airway wall model of remodeling
Am J Physiol Lung Cell Mol Physiol, August 1, 2003; 285(2): L427 - L433.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. E. McParland, P. T. Macklem, and P. D. Pare
Airway wall remodeling: friend or foe?
J Appl Physiol, July 1, 2003; 95(1): 426 - 434.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Nucci, B. Suki, and K. Lutchen
Modeling airflow-related shear stress during heterogeneous constriction and mechanical ventilation
J Appl Physiol, July 1, 2003; 95(1): 348 - 356.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
L. Wang, B. E. McParland, and P. D. Pare
The Functional Consequences of Structural Changes in the Airways: Implications for Airway Hyperresponsiveness in Asthma
Chest, March 1, 2003; 123(2007): 356S - 362S.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. A. Olman
Epithelial Cell Modulation of Airway Fibrosis in Asthma
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 125 - 128.
[Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. J. Tschumperlin, J. D. Shively, T. Kikuchi, and J. M. Drazen
Mechanical Stress Triggers Selective Release of Fibrotic Mediators from Bronchial Epithelium
Am. J. Respir. Cell Mol. Biol., February 1, 2003; 28(2): 142 - 149.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
P A Beckett and P H Howarth
Pharmacotherapy and airway remodelling in asthma?
Thorax, February 1, 2003; 58(2): 163 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. J. Fredberg
Airway narrowing in asthma: does speed kill?
Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1179 - L1180.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D. J. Tschumperlin, J. D. Shively, M. A. Swartz, E. S. Silverman, K. J. Haley, G. Raab, and J. M. Drazen
Mechanotransduction in the Lung: Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression
Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L904 - L911.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. S. Kott, K. E. Pinkerton, J. M. Bric, C. G. Plopper, K. P. Avadhanam, and J. P. Joad
Methacholine responsiveness of proximal and distal airways of monkeys and rats using videomicrometry
J Appl Physiol, March 1, 2002; 92(3): 989 - 996.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Latourelle, B. Fabry, and J. J. Fredberg
Dynamic equilibration of airway smooth muscle contraction during physiological loading
J Appl Physiol, February 1, 2002; 92(2): 771 - 779.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. J. TSCHUMPERLIN and J. M. DRAZEN
Mechanical Stimuli to Airway Remodeling
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): S90 - 94.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Milanese, E. Crimi, A. Scordamaglia, A. Riccio, R. Pellegrino, G. W. Canonica, and V. Brusasco
On the functional consequences of bronchial basement membrane thickening
J Appl Physiol, September 1, 2001; 91(3): 1035 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
U. Holzhauser and R. K. Lambert
Analysis of tracheal mechanics and applications
J Appl Physiol, July 1, 2001; 91(1): 290 - 297.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Lambert, P. D. Pare, and M. Okazawa
Stiffness of peripheral airway folding membrane in rabbits
J Appl Physiol, June 1, 2001; 90(6): 2041 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. WOHLSEN, S. UHLIG, and C. MARTIN
Immediate Allergic Response in Small Airways
Am. J. Respir. Crit. Care Med., May 1, 2001; 163(6): 1462 - 1469.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
M. Okazawa, P. D. Pare, and R. K. Lambert
Compliance of peripheral airways deduced from morphometry
J Appl Physiol, December 1, 2000; 89(6): 2373 - 2381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H. J. L. BRACKEL, O. F. PEDERSEN, P. G. H. MULDER, S. E. OVERBEEK, K. F. KERREBIJN, and J. M. BOGAARD
Central Airways Behave More Stiffly during Forced Expiration in Patients with Asthma
Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 896 - 904.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. I. Blyth, T. F. Wharton, M. S. Pedrick, T. J. Savage, and S. Sanjar
Airway Subepithelial Fibrosis in a Murine Model of Atopic Asthma . Suppression by Dexamethasone or Anti-Interleukin-5 Antibody
Am. J. Respir. Cell Mol. Biol., August 1, 2000; 23(2): 241 - 246.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
B. Ressler, R. T. Lee, S. H. Randell, J. M. Drazen, and R. D. Kamm
Molecular responses of rat tracheal epithelial cells to transmembrane pressure
Am J Physiol Lung Cell Mol Physiol, June 1, 2000; 278(6): L1264 - L1272.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Wang, R. Tepper, J. L. Bert, K. L. Pinder, P. D. Pare, and M. Okazawa
Mechanical properties of the tracheal mucosal membrane in the rabbit. I. Steady-state stiffness as a function of age
J Appl Physiol, March 1, 2000; 88(3): 1014 - 1021.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Wang, K. L. Pinder, J. L. Bert, M. Okazawa, and P. D. Pare
Mechanical properties of the tracheal mucosal membrane in the rabbit. II. Morphometric analysis
J Appl Physiol, March 1, 2000; 88(3): 1022 - 1028.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Y. Seow, L. Wang, and P. D. Pare
Airway narrowing and internal structural constraints
J Appl Physiol, February 1, 2000; 88(2): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. PALMANS, J. C. KIPS, and R. A. PAUWELS
Prolonged Allergen Exposure Induces Structural Airway Changes in Sensitized Rats
Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): 627 - 635.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
H. L. Gillis and K. R. Lutchen
Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness
J Appl Physiol, June 1, 1999; 86(6): 2001 - 2012.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. J. FREDBERG, D. S. INOUYE, S. M. MIJAILOVICH, and J. P. BUTLER
Perturbed Equilibrium of Myosin Binding in Airway Smooth Muscle and Its Implications in Bronchospasm
Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 959 - 967.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
J. J. Fredberg and S. A. Shore
Invited Editorial on "Influence of intercellular tissue connections on airway muscle mechanics"
J Appl Physiol, January 1, 1999; 86(1): 3 - 4.
[Full Text] [PDF]

Home page
 ThoraxHome page
V. Brusasco, E. Crimi, and R. Pellegrino
Airway hyperresponsiveness in asthma: not just a matter of airway inflammation
Thorax, November 1, 1998; 53(11): 992 - 998.
[Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Swartz, D. J. Tschumperlin, R. D. Kamm, and J. M. Drazen
Mechanical stress is communicated between different cell types to elicit matrix remodeling
PNAS, May 22, 2001; 98(11): 6180 - 6185.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online