| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 83, Issue 5, 1756-1761, 1997
Departments of 1 Internal Medicine, 2 Pediatrics, and 3 Pharmacology, University of Virginia Health Sciences Center, and 4 Department of Human Services, University of Virginia, Charlottesville, Virginia 22908
Received 2 May 1997; accepted in final form 9 July 1997.
Kanaley, J. A., J. Y. Weltman, J. D. Veldhuis, A. D. Rogol,
M. L. Hartman, and A. Weltman. Human growth hormone response to
repeated bouts of aerobic exercise. J. Appl.
Physiol. 83(5): 1756-1761, 1997.
We examined
whether repeated bouts of exercise could override growth hormone (GH)
auto-negative feedback. Seven moderately trained men were studied on
three occasions: a control day (C), a sequential exercise day (SEB; at
1000, 1130, and 1300), and a delayed exercise day (DEB; at 1000, 1400, and 1800). The duration of each exercise bout was 30 min at 70%
maximal O2 consumption (
O2 max) on a cycle
ergometer. Standard meals were provided at 0600 and 2200. GH was
measured every 5-10 min for 24 h (0800-0800). Daytime
(0800-2200) integrated GH concentrations were ~150-160% greater during SEB and DEB than during C: 1,282 ± 345, 3,192 ± 669, and 3,389 ± 991 min · µg · l
1
for C, SEB, and DEB, respectively [SEB > C
(P < 0.06), DEB > C
(P < 0.03)]. There were no
differences in GH release during sleep (2300-0700). Deconvolution
analysis revealed that the increase in 14-h integrated GH concentration
on DEB was accounted for by an increase in the mass of GH secreted per
pulse (per liter of distribution volume,
lv): 7.0 ± 2.9 and 15.9 ± 2.6 µg/lv for C and DEB,
respectively (P < 0.01). Comparison
of 1.5-h integrated GH concentrations on the SEB and DEB days (30 min
exercise + 60 min recovery) revealed that, with each subsequent
exercise bout, GH release apparently increased progressively, with a
slightly greater increase on the DEB day [SEB vs. DEB: 497 ± 162 vs. 407 ± 166 (bout 1), 566 ± 152 vs. 854 ± 184 (bout
2), and 633 ± 149 vs. 1,030 ± 352 min · µg · l1
(bout 3),
P < 0.05]. We conclude that
the GH response to acute aerobic exercise is augmented with repeated
bouts of exercise.
endocrinology; deconvolution
This article has been cited by other articles:
|
|
 |
|
  C. Moro, F. Pillard, I. de Glisezinski, E. Klimcakova, F. Crampes, C. Thalamas, I. Harant, M.-A. Marques, M. Lafontan, and M. Berlan Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E505 - E513. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Sartorio, M Jubeau, F Agosti, A De Col, N Marazzi, C L Lafortuna, and N A Maffiuletti GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults Eur. J. Endocrinol., March 1, 2008; 158(3): 311 - 316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Stokes, C. Tyler, and K. L. Gilbert The growth hormone response to repeated bouts of sprint exercise with and without suppression of lipolysis in men J Appl Physiol, March 1, 2008; 104(3): 724 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gibney, M.-L. Healy, and P. H. Sonksen The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport Endocr. Rev., October 1, 2007; 28(6): 603 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Goto, N. Ishii, A. Mizuno, and K. Takamatsu Enhancement of fat metabolism by repeated bouts of moderate endurance exercise J Appl Physiol, June 1, 2007; 102(6): 2158 - 2164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wideman, L. Consitt, J. Patrie, B. Swearingin, R. Bloomer, P. Davis, and A. Weltman The impact of sex and exercise duration on growth hormone secretion J Appl Physiol, December 1, 2006; 101(6): 1641 - 1647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Tuckow, K. R. Rarick, W. J. Kraemer, J. O. Marx, W. C. Hymer, and B. C. Nindl Nocturnal growth hormone secretory dynamics are altered after resistance exercise: deconvolution analysis of 12-hour immunofunctional and immunoreactive isoforms Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1749 - R1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Moro, J. Polak, J. Hejnova, E. Klimcakova, F. Crampes, V. Stich, M. Lafontan, and M. Berlan Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E864 - E869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sartorio, F. Agosti, P. G. Marinone, M. Proietti, C. L. Lafortuna, N. A. Maffiuletti, K. Stokes, M. Nevill, H. Lakomy, J. Frystyk, et al. Growth hormone responses to repeated bouts of aerobic exercise with different recovery intervals J Appl Physiol, March 1, 2006; 100(3): 1093 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Stokes, M. Nevill, J. Frystyk, H. Lakomy, and G. Hall Human growth hormone responses to repeated bouts of sprint exercise with different recovery periods between bouts J Appl Physiol, October 1, 2005; 99(4): 1254 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Veldhuis, J. Patrie, L. Wideman, M. Patterson, J. Y. Weltman, and A. Weltman Contrasting Negative-Feedback Control of Endogenously Driven and Exercise-Stimulated Pulsatile Growth Hormone Secretion in Women and Men J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kanaley, R. Dall, N. Moller, S. C. Nielsen, J. S. Christiansen, M. D. Jensen, and J. O. L. Jorgensen Acute exposure to GH during exercise stimulates the turnover of free fatty acids in GH-deficient men J Appl Physiol, February 1, 2004; 96(2): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M J Rennie Claims for the anabolic effects of growth hormone: a case of the Emperor's new clothes? Br. J. Sports Med., April 1, 2003; 37(2): 100 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Stokes, M. E. Nevill, G. M. Hall, and H. K. A. Lakomy Growth hormone responses to repeated maximal cycle ergometer exercise at different pedaling rates J Appl Physiol, February 1, 2002; 92(2): 602 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Galassetti, S. Mann, D. Tate, R. A. Neill, D. H. Wasserman, and S. N. Davis Effect of morning exercise on counterregulatory responses to subsequent, afternoon exercise J Appl Physiol, July 1, 2001; 91(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Nindl, W. C. Hymer, D. R. Deaver, and W. J. Kraemer Growth hormone pulsatility profile characteristics following acute heavy resistance exercise J Appl Physiol, July 1, 2001; 91(1): 163 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Kanaley, J. Y. Weltman, K. S. Pieper, A. Weltman, and M. L. Hartman Cortisol and Growth Hormone Responses to Exercise at Different Times of Day J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2881 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wideman, J. Y. Weltman, J. T. Patrie, C. Y. Bowers, N. Shah, S. Story, J. D. Veldhuis, and A. Weltman Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1467 - R1477. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Weltman, C. J. Pritzlaff, L. Wideman, J. Y. Weltman, J. L. Blumer, R. D. Abbott, M. L. Hartman, and J. D. Veldhuis Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow J Appl Physiol, August 1, 2000; 89(2): 629 - 635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Eliakim, Y. Oh, and D. M. Cooper Effect of single wrist exercise on fibroblast growth factor-2, insulin-like growth factor, and growth hormone Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2000; 279(2): R548 - R553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stich, I. de Glisezinski, M. Berlan, J. Bulow, J. Galitzky, I. Harant, H. Suljkovicova, M. Lafontan, D. Riviere, and F. Crampes Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise J Appl Physiol, April 1, 2000; 88(4): 1277 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wideman, J. Y. Weltman, N. Shah, S. Story, J. D. Veldhuis, and A. Weltman Effects of gender on exercise-induced growth hormone release J Appl Physiol, September 1, 1999; 87(3): 1154 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Pritzlaff, L. Wideman, J. Y. Weltman, R. D. Abbott, M. E. Gutgesell, M. L. Hartman, J. D. Veldhuis, and A. Weltman Impact of acute exercise intensity on pulsatile growth hormone release in men J Appl Physiol, August 1, 1999; 87(2): 498 - 504. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
