| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 83, Issue 5, 1721-1732, 1997
1 Department of Environmental
and Occupational Medicine, University of Aarhus, DK-8000 Aarhus C,
Denmark; 2 University Hospital for
Children and Youth "Wilhelmina Children's Hospital",
Received 14 February 1997; accepted in final form 15 July 1997.
Pedersen, O. F., H. J. L. Brackel, J. M. Bogaard, and K. F. Kerrebijn. Wave-speed-determined flow limitation at peak flow in
normal and asthmatic subjects. J. Appl.
Physiol. 83(5): 1721-1732, 1997.
peak expiratory flow; peak flow-determining factors
The purpose of
this study was to examine whether peak expiratory flow is determined by
the wave-speed flow-limiting mechanism. We examined 17 healthy subjects
and 11 subjects with stable asthma, the latter treated with inhaled
bronchodilators and corticosteroids. We used an esophageal balloon and
a Pitot-static probe positioned at five locations between the right
lower lobe and midtrachea to obtain dynamic area-transmural pressure
(A-Ptm) curves as described (O. F. Pedersen, B. Thiessen, and S. Lyager. J. Appl.
Physiol. 52: 357-369, 1982). From these curves we
obtained cross-sectional area (A)
and airway compliance (Caw = dA/dPtm) at PEF, calculated flow at wave speed {
ws = A[A/(Caw*
)0.5],
where is density} and speed index is (SI = /ws). In 13 of 15 healthy and
in 4 of 10 asthmatic subjects, who could produce satisfactory curves,
SI at PEF was >0.9 at one or more measured positions. Alveolar
pressure continued to increase after PEF was achieved, suggesting flow
limitation somewhere in the airway in all of these subjects. We
conclude that wave speed is reached in central airways at PEF in most
subjects, but it cannot be excluded that wave speed is also reached in
more peripheral airways.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
This article has been cited by other articles:
|
|
 |
|
  P J F M Merkus Mould eradication and asthma Thorax, April 1, 2008; 63(4): 385 - 385. [Full Text] [PDF]
|
|
|
|
 |
|
 P. J.F.M. Merkus, L. Terracciano, A. Fiocchi, G. R. Bouygue, A. Papi, G. Nicolini, and L. M. Fabbri Beclomethasone and albuterol in mild asthma. N. Engl. J. Med., August 2, 2007; 357(5): 506 - 506. [Full Text] [PDF]
|
|
|
|
|
|
P. T. Macklem, A. R.L. Medford, A. Agrawal, G. Cox, N. C. Thomson, and M. Laviolette Bronchial Thermoplasty N. Engl. J. Med., June 28, 2007; 356(26): 2744 - 2745. [Full Text] [PDF]
|
|
|
|
 |
|
 N. Aljuri, J. G. Venegas, and L. Freitag Viscoelasticity of the trachea and its effects on flow limitation J Appl Physiol, February 1, 2006; 100(2): 384 - 389. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Tzelepis Peak Expiratory Flow Time in Amyotrophic Lateral Sclerosis Chest, September 1, 2005; 128(3): 1889 - 1890. [Full Text] [PDF]
|
|
|
|
|
|
T. Omar, H. Alawadhi, A. O. Soubani, and G. E. Tzelepis Peak Expiratory Flow With or Without a Brief Postinspiratory Pause Chest, July 1, 2005; 128(1): 442 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Farre, J. Rigau, J. M. Montserrat, L. Buscemi, E. Ballester, and D. Navajas Static and Dynamic Upper Airway Obstruction in Sleep Apnea: Role of the Breathing Gas Properties Am. J. Respir. Crit. Care Med., September 15, 2003; 168(6): 659 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. McParland, P. T. Macklem, and P. D. Pare Airway wall remodeling: friend or foe? J Appl Physiol, July 1, 2003; 95(1): 426 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Tantucci, A. Duguet, P. Giampiccolo, T. Similowski, M. Zelter, and J.-P. Derenne The Best Peak Expiratory Flow Is Flow-Limited and Effort-Independent in Normal Subjects Am. J. Respir. Crit. Care Med., May 1, 2002; 165(9): 1304 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. L. BRACKEL, O. F. PEDERSEN, P. G. H. MULDER, S. E. OVERBEEK, K. F. KERREBIJN, and J. M. BOGAARD Central Airways Behave More Stiffly during Forced Expiration in Patients with Asthma Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 896 - 904. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Miller and O. F. Pedersen Peak flowmeter resistance decreases peak expiratory flow in subjects with COPD J Appl Physiol, July 1, 2000; 89(1): 283 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. F. Pedersen, T. F. Pedersen, and M. R. Miller Gas compression in lungs decreases peak expiratory flow depending on resistance of peak flowmeter J Appl Physiol, November 1, 1997; 83(5): 1517 - 1521. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
