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Vol. 83, Issue 5, 1706-1710, 1997
1 Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262; 2 Department of Chest Medicine, School of Medicine, Chiba University, Chiba 260, Japan; and 3 Department of Anthropology, University of Colorado at Denver, Denver, Colorado 80217
Received 15 July 1996; accepted in final form 11 July 1997.
Tatsumi, Koichiro, Cheryl K. Pickett, Christopher R. Jacoby,
John V. Weil, and Lorna G. Moore. Role of endogenous female hormones in hypoxic chemosensitivity. J. Appl.
Physiol. 83(5): 1706-1710, 1997.
Effective alveolar ventilation and hypoxic
ventilatory response (HVR) are higher in females than in males and
after endogenous or exogenous elevation of progesterone and estrogen.
The contribution of normal physiological levels of ovarian hormones to
resting ventilation and ventilatory control and whether their site(s) of action is central and/or peripheral are unclear.
Accordingly, we examined resting ventilation, HVR, and hypercapnic
ventilatory responses (HCVR) before and 3 wk after ovariectomy in five
female cats. We also compared carotid sinus nerve (CSN) and central
nervous system translation responses to hypoxia in 6 ovariectomized and 24 intact female animals. Ovariectomy decreased serum progesterone but
did not change resting ventilation, end-tidal
PCO2, or HCVR (all
P = NS). Ovariectomy reduced the
HVR shape parameter A in the awake
(38.9 ± 5.5 and 21.2 ± 3.0 before and after ovariectomy, respectively, P < 0.05) and
anesthetized conditions. The CSN response to hypoxia was lower in
ovariectomized than in intact animals (shape parameter
A = 22.6 ± 2.5 and 54.3 ± 3.5 in ovariectomized and intact animals, respectively,
P < 0.05), but central nervous system translation of CSN activity into ventilation was similar in
ovariectomized and intact animals. We concluded that ovariectomy decreased ventilatory and CSN responsiveness to hypoxia, suggesting that the presence of physiological levels of ovarian hormones influences hypoxic chemosensitivity by acting primarily at peripheral sites.
progesterone; estrogen; carotid body; ovariectomy; hypercapnic ventilatory response
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