Journal of Applied Physiology AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1690-1696, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Madwed, J. B.
Right arrow Articles by Jackson, A. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Madwed, J. B.
Right arrow Articles by Jackson, A. C.

Vol. 83, Issue 5, 1690-1696, 1997

Determination of airway and tissue resistances after antigen and methacholine in nonhuman primates

Jeffrey B. Madwed1 and Andrew C. Jackson2

1 Department of Immunological Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877; and 2 Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02115

Received 9 July 1996; accepted in final form 8 July 1997.

Madwed, Jeffrey B., and Andrew C. Jackson. Determination of airway and tissue resistances after antigen and methacholine in nonhuman primates. J. Appl. Physiol. 83(5): 1690-1696, 1997.---Antigen challenge of Ascaris suum-sensitive animals has been used as a model of asthma in humans. However, no reports have separated total respiratory resistance into airway (Raw) and tissue (Rti) components. We compared input impedance (Zin) and transfer impedance (Ztr) to determine Raw and Rti in anesthetized cynomolgus monkeys under control and bronchoconstricted conditions. Zin data between 1 and 64 Hz are frequency dependent during baseline conditions, and this frequency dependence shifts in response to A. suum or methacholine. Thus it cannot be modeled with the DuBois model, and estimates of Raw and Rti cannot be determined. With Ztr, baseline data were much less variable than Zin in all monkeys. After bronchial challenge with A. suum or methacholine, the absolute amplitude of the resistive component of Ztr increased and its zero crossing shifted to higher frequencies. These data can estimate Raw and Rti with the six-element DuBois model. Therefore, in monkeys, Ztr has advantages over other measures of lung function, since it provides a methodology to separate estimates of Raw and Rti. In conclusion, Ztr shows spectral features similar to those reported in healthy and asthmatic humans.

input impedance; transfer impedance; forced oscillations; cynomolgus monkeys

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. M. Dybas, C. J. Andresen, E. S. Schelegle, R. W. McCue, N. N. Callender, and A. C. Jackson
Deep-breath frequency in bronchoconstricted monkeys (Macaca fascicularis)
J Appl Physiol, March 1, 2006; 100(3): 786 - 791.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. L. Coffman and E. M. Hessel
Nonhuman primate models of asthma
J. Exp. Med., June 20, 2005; 201(12): 1875 - 1879.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
P. Nassar, A. Jackson, and D. Carrier
Entraining the natural frequencies of running and breathing in guinea fowl (Numida meleagris)
J. Exp. Biol., May 1, 2001; 204(9): 1641 - 1651.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
E. S. Schelegle, L. J. Gershwin, L. A. Miller, M. V. Fanucchi, L. S. Van Winkle, J. P. Gerriets, W. F. Walby, A. M. Omlor, A. R. Buckpitt, B. K. Tarkington, et al.
Allergic Asthma Induced in Rhesus Monkeys by House Dust Mite (Dermatophagoides farinae)
Am. J. Pathol., January 1, 2001; 158(1): 333 - 341.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online