Journal of Applied Physiology AJP: Cell Physiology
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J Appl Physiol 83: 1666-1670, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1666-1670, 1997

Partial liquid ventilation protects lung during resuscitation from shock

John G. Younger1, Ali S. Taqi1, Gerd O. Till2, and Ronald B. Hirschl3

1 Sections of Emergency Medicine and 3 Pediatric Surgery, and 2 Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109

Received 10 February 1997; accepted in final form 18 July 1997.

Younger, John G., Ali S. Taqi, Gerd O. Till, and Ronald B. Hirschl. Partial liquid ventilation protects lung during resuscitation from shock. J. Appl. Physiol. 83(5): 1666-1670, 1997.---Preliminary animal experience with partial liquid ventilation (PLV) suggests that this therapy may diminish neutrophil invasion and capillary leak during acute lung injury. We sought to confirm these findings in a model of shock-induced lung injury. Sixty anesthetized rats were studied. After hemorrhage to an arterial pressure of 25 mmHg for 45 min, animals were resuscitated with blood and saline and treated with gas ventilation alone or with 5 ml/kg of intratracheally administered perflubron. Myeloperoxidase activity was used to measure lung neutrophil content. A permeability index (the bronchoalveolar-to-blood ratio of 125I-labeled albumin activity) quantified alveolar leak. Injury caused an increase in myeloperoxidase that was reversed by PLV (injury = 0.837 ± 0.452, PLV = 0.257 ± 0.165; P < 0.01). Capillary permeability also increased with hemorrhage, with a strong trend toward improvement in the PLV group (permeability indexes: injury = 0.094 ± 0.102, PLV = 0.045 ± 0.045; 95% confidence interval for injury - PLV: -0.024, 0.1219). We conclude that PLV is associated with a decrease in pulmonary neutrophil accumulation and a trend toward decreased capillary leak after hemorrhagic shock.

acute lung injury; reperfusion injury; hemorrhagic shock; perfluorocarbon

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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