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J Appl Physiol 83: 1641-1647, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1641-1647, 1997

Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis

Ashish R. Shah1, Thomas G. Keens1, and David Gozal2

1 Division of Pediatric Pulmonology, Childrens Hospital Los Angeles, and Department of Pediatrics, University of Southern California School of Medicine, Los Angeles, California 90027; and 2 Constance S. Kaufman Pediatric Pulmonary Research Laboratory, Departments of Pediatrics and Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112

Received 25 June 1996; accepted in final form 27 June 1997.

Shah, Ashish R., Thomas G. Keens, and David Gozal. Effect of supplemental oxygen on supramaximal exercise performance and recovery in cystic fibrosis. J. Appl. Physiol. 83(5): 1641-1647, 1997.---The effects of supplemental O2 on recovery from supramaximal exercise and subsequent performance remain unknown. If recovery from exercise could be enhanced in individuals with chronic lung disease, subsequent supramaximal exercise performance could also be improved. Recovery from supramaximal exercise and subsequent supramaximal exercise performance were assessed after 10 min of breathing 100% O2 or room air (RA) in 17 cystic fibrosis (CF) patients [25 ± 10 (SD) yr old, 53% men, forced expired volume in 1 s = 62 ± 21% predicted] and 17 normal subjects (25 ± 8 yr old, 59% men, forced expired volume in 1 s = 112 ± 15% predicted). Supramaximal performance was assessed as the work of sustained bicycling at a load of 130% of the maximum load achieved during a graded maximal exercise. Peak minute ventilation (VE) and heart rate (HR) were lower in CF patients at the end of each supramaximal bout than in controls. In CF patients, single-exponential time decay constants indicated faster recovery of HR (tau HR = 86 ± 8 and 73 ± 6 s in RA and O2, respectively, P < 0.01). Similarly, fast and slow time constants of two-exponential equations providing the best fit for ventilatory recovery were improved in CF patients during O2 breathing (&tgr;<SUB>1 <A><AC>V</AC><AC>˙</AC></A><SC>e</SC></SUB> = 132.1 ± 10.5 vs. 82.5 ± 10.4 s; &tgr;<SUB>2 <A><AC>V</AC><AC>˙</AC></A><SC>e</SC></SUB> = 880.3 ± 300.1 vs. 368.6 ± 107.1 s, P < 0.01). However, no such improvements occurred in controls. Supramaximal performance after O2 improved in CF patients (109 ± 6% of the 1st bout after O2 vs. 94 ± 6% in RA, P < 0.01). O2 supplementation had no effect on subsequent performance in controls (97 ± 3% in O2 vs. 93 ± 3% in RA). We conclude that supplemental O2 after a short bout of supramaximal exercise accelerates recovery and preserves subsequent supramaximal performance in patients with CF.

obstructive lung disease; gas exchange

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society






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