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J Appl Physiol 83: 1617-1622, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1617-1622, 1997

Flow-induced responses in cat isolated pulmonary arteries

Larissa A. Shimoda1, Nan A. Norins2, and Jane A. Madden3,4

1 Department of Biomedical Engineering, Marquette University, Milwaukee 53233; 2 Departments of Pediatrics and 3 Neurology, The Medical College of Wisconsin, Milwaukee 53226; and 4 Research Service, Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295

Received 22 November 1996; accepted in final form 16 July 1997.

Shimoda, Larissa A., Nan A. Norins, and Jane A. Madden. Flow-induced responses in cat isolated pulmonary arteries. J. Appl. Physiol. 83(5): 1617-1622, 1997.---Isolated, cannulated, endothelium-intact cat pulmonary arteries, averaging 692 ± 104 µm in diameter, were set at a transmural pressure of 10 mmHg and monitored with a video system. Intraluminal flow was increased in steps from 0 to 1.6 ml/min by using a syringe pump. An electronic system held pressure constant by changing outflow resistance. Flow-diameter curves were generated in physiological saline solution. At constant transmural pressure, the arteries constricted in response to increased intraluminal flow. Constriction was not affected by removing extracellular Ca2+ but was abolished after treatment with ryanodine to deplete intracellular Ca2+ stores, with the endothelin-1 synthesis inhibitor phosphoramidon, with the endothelin A-receptor antagonist BQ-123, with the protein kinase C inhibitor staurosporine, or with glutaraldehyde to reduce endothelial cell deformability. The results indicate that isolated pulmonary arteries can constrict in response to intraluminal flow and suggest that constriction is mediated by endothelin-1 and depends on intracellular Ca2+ release and protein kinase C activation.

endothelin-1; BQ-123; shear stress




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