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Vol. 83, Issue 5, 1607-1611, 1997
Systems Neurobiology Laboratory, Departments of Physiological Science and Neurobiology, University of California, Los Angeles, California 90095-1527
Received 30 January 1997; accepted in final form 4 July 1997.
Mellen, Nicholas M., and Jack L. Feldman.
Vagal stimulation induces expiratory lengthening in the in vitro
neonate rat. J. Appl. Physiol. 83(5):
1607-1611, 1997.
Respiration is modulated by lung mechanoreceptor
feedback in vivo on a cycle-to-cycle basis. We replicated this
modulation in vitro and tested four stimulus protocols to identify
which of these most closely replicated in vivo responses to lung
mechanoreceptor activation in mammals. We activated pulmonary vagal
afferent pathways by electrical stimulation or by lung inflation,
applied during expiration, which produces expiratory lengthening in
vivo. In each modality, transient and tonic stimuli were applied.
Stimuli were applied over a range of delays following inspiratory
termination. Tonic stimuli were maintained until subsequent inspiratory
onset. All stimulus modalities prolonged expiration
(P < 0.05). These results indicate
that the neural circuitry mediating pulmonary afferent modulation of
expiratory duration is retained in vitro.
pulmonary afferents; lung; vagus; medulla
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