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J Appl Physiol 83: 1595-1601, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1595-1601, 1997

Mechanical impedance of the lung periphery

Z. Hantos1, F. Peták1, Á. Adamicza2, T. Asztalos1, J. Tolnai1, and J. J. Fredberg3

Departments of 1 Medical Informatics and 2 Experimental Surgery, Albert Szent-Györgyi Medical University, H-6720 Szeged, Hungary; and 3 Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115

Received 21 January 1997; accepted in final form 1 July 1997.

Hantos, Z., F. Peták, Á. Adamicza, T. Asztalos, J. Tolnai, and J. J. Fredberg. Mechanical impedance of the lung periphery. J. Appl. Physiol. 83(5): 1595-1601, 1997.---The mechanics of the regional airways and tissues was studied in isolated dog lobes by means of a modified wave-tube technique. Small-amplitude pseudorandom forced oscillations between 0.1 and 48 Hz were applied through catheters wedged in 2-mm-diameter bronchi in three regions of each lobe at translobar pressures (PL) of 10, 7, 5, 3, 2, and 1 cmH2O. The measured regional input impedances were fitted by a model containing the resistance (R1) and inertance (I) of the regular (segmental) airways, the resistance of the collateral channels (R2), and the damping (G) and elastance (H) of the local tissues. This model gave far better fits to the data on impedance of the lung periphery than when G and H were replaced by a single tissue compliance, which explains why interruption of segmental flow did not lead to monoexponential pressure decay in previous studies. The interlobar and intralobar variances of the parameters were equally significant, and poor correlations were found between the airway parameters R1 and R2 and between any airway and tissue parameter (e.g., R1 and H). R2 was on average ~10 times higher than R1, although the R2-to-R1 ratios and their dependencies on PL were regionally highly variable. However, for the total of 33 regions studied, the PL dependence was the same for R1 and R2, which may reflect similar morphological structures for the regular and collateral airways. The dependencies of G and H on PL showed high interregional variations; generally, however, they assumed their minima at medium PL values (~5 cmH2O).

collateral airways; collateral resistance; airway resistance; pulmonary elastance; lung tissue resistance

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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