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Vol. 83, Issue 5, 1575-1580, 1997
Departments of Anesthesiology and Physiology, Veterans Affairs Medical Center and Medical College of Wisconsin, Milwaukee, Wisconsin 53295
Received 26 December 1996; accepted in final form 11 July 1997.
Buckwalter, John B., Patrick J. Mueller, and Philip S. Clifford. Sympathetic vasoconstriction in active skeletal muscles during dynamic exercise. J. Appl.
Physiol. 83(5): 1575-1580, 1997.
Studies utilizing systemic administration of 
-adrenergic antagonists have
failed to demonstrate sympathetic vasoconstriction in working muscles
during dynamic exercise. The purpose of this study was to examine the
existence of active sympathetic vasoconstriction in working skeletal
muscles by using selective intra-arterial blockade. Six mongrel dogs
were instrumented chronically with flow probes on the external iliac
arteries of both hindlimbs and with a catheter in one femoral artery.
All dogs ran on a motorized treadmill at three intensities on separate
days. After 2 min, the selective
1-adrenergic antagonist
prazosin (0.1 mg) was infused as a bolus into the femoral artery
catheter. At mild, moderate, and heavy workloads, there were immediate
increases in iliac conductance of 76 ± 7, 54 ± 11, and 22 ± 6% (mean ± SE), respectively. Systemic blood pressure and blood
flow in the contralateral iliac artery were unaffected. These results
demonstrate that there is sympathetic vasoconstriction in active
skeletal muscles even at high exercise intensities.
blood flow; -adrenergic receptor; autonomic nervous system; prazosin; dogs
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