Journal of Applied Physiology
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J Appl Physiol 83: 1566-1574, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1566-1574, 1997

Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits

Marie-Reine Losser1, Catherine Bernard1,2, Jean-Louis Beaudeux3, Christophe Pison4, and Didier Payen1

1 Laboratoire de Recherche, Département d'Anesthésie-Réanimation, 2 Institut National de la Santé et de la Recherche Médicale U141, and 3 Laboratoire de Biochimie, Hôpital Lariboisière, 75475 Paris Cedex 10; and 4 Laboratoire de Thérapeutique, Grenoble, 38043 Cedex 09 France

Received 2 September 1996; accepted in final form 3 July 1997.

Losser, Marie-Reine, Catherine Bernard, Jean-Louis Beaudeux, Christophe Pison, and Didier Payen. Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits. J. Appl. Physiol. 83(5): 1566-1574, 1997.---Glucose is important for vascular and immunocompetent cell functions. We hypothesized that modifications in glucose metabolism (normal feeding, 24-h fasting, glucose loading) may influence the hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide administration (LPS; 600 µg/kg iv) in rabbits. Aortic (ABFV), hepatic artery (HABFV), and portal vein blood flow velocities (PVBFV) (pulsed Doppler), plasma tumor necrosis factor (TNF) and nitrites were measured. Fasting depleted hepatic glycogen content, and intraportal glucose load (2 g/kg) partially restored it. LPS induced a similar hypotension (-20%, P < 0.05) in three groups of animals. In fed animals, systemic vasoconstriction occured with low ABFV and PVBFV (-40%, P < 0.05), together with lactacidemia and hyperglycemia. In fasted animals, ABFV and PVBFV were maintained, without metabolic acidosis or hyperglycemia. Glucose loading induced hemodynamic and metabolic patterns comparable to those observed in fed animals, although significantly more severe. TNF release was amplified fourfold by glucose loading, with no impact on nitrite levels. In conclusion, glucose metabolism interferes with hemodynamic, metabolic, and inflammatory responses to LPS.

liver blood flow; tumor necrosis factor; metabolism

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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