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Vol. 83, Issue 5, 1551-1556, 1997
Interuniversity Project on Reproductive Endocrinology in Women and Exercise, 1 Department of Applied and Experimental Reproductive Endocrinology, B-3000 Leuven 3, Belgium; 2 Department of Biochemical and Clinical Endocrinology, Medical University of Lübeck, D-23538 Lübeck, Germany; and 3 Department of Movement Sciences, Faculty of Health Sciences, University of Maastricht, NL-6200 MD Maastricht, The Netherlands
Received 11 February 1997; accepted in final form 16 June 1997.
De Crée, Carl, Peter Ball, Bärbel
Seidlitz, Gerrit Van Kranenburg, Peter Geurten, and Hans A. Keizer.
Effects of a training program on resting plasma
2-hydroxycatecholestrogen levels in eumenorrheic women.
J. Appl. Physiol. 83(5):
1551-1556, 1997.
Catecholestrogens (CE) represent a major
metabolic pathway in estrogen metabolism. Previous information on CE
and training is limited to two cross-sectional studies that did not
involve standardized training. Our purpose, by means of a prospective design, was to evaluate the effects of a brief, exhaustive training program on resting plasma concentrations of 2-hydroxy CE. The experimental design spanned two menstrual cycles: a control cycle and a
training cycle. The subjects were nine previously untrained, eumenorrheic women [body fat: 24.8 ± 1.0 (SE) %]. Data
were collected during the follicular (FPh) and the luteal phases (LPh).
Posttraining FPh and LPh tests were held the day after the last day of
a 5-day period of training on a cycle ergometer. Total
2-hydroxyestrogens (2-OHE) averaged 200 ± 29 pg/ml during the FPh
and 420 ± 54 pg/ml during the LPh
(P < 0.05). Levels of total
2-methoxyestrogens (2-MeOE) were 237 ± 32 pg/ml during the FPh and
339 ± 26 pg/ml during the LPh (P < 0.05). After training, although the plasma levels of 2-OHE
significantly decreased (
21%;
P < 0.05) during the LPh, the actual
CE formation (as estimated from the 2-OHE-to-total estrogens ratio)
increased (+29%; P < 0.05). CE activity, as expressed by the 2-MeOE-to-2-OHE ratio, showed
significantly higher values in both phases (FPh, +14%; LPh, +13%;
P < 0.05). At the same time, resting
levels of norepinephrine (NE) were increased by 42%
(P < 0.05). CE strongly inhibit
biological decomposition of NE by catechol-O-methyltransferase (COMT).
Results of the present study suggest that, in response to training, CE
are increasingly competing with the enzyme COMT, thus preventing
premature NE deactivation.
amenorrhea; anovulation; catecholamines; catechol-Omethyltransferase; estrogens; 2-hydroxylase
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