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Vol. 83, Issue 5, 1538-1544, 1997
Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14222
Received 14 May 1997; accepted in final form 26 June 1997.
Cummings, James J. Nitric oxide decreases lung liquid
production in fetal lambs. J. Appl.
Physiol. 83(5): 1538-1544, 1997.
To examine the
effect of nitric oxide on fetal lung liquid production, I measured lung
liquid production in fetal sheep at 130 ± 5 days gestation (range
122-137 days) before and after intrapulmonary instillation of
nitric oxide. Thirty-one studies were done in which net lung luminal
liquid production (Jv) was measured by plotting the change in lung luminal liquid concentration of
radiolabeled albumin, an impermeant tracer that was mixed into the lung
liquid at the start of each study. To see whether changes in
Jv
might be associated with changes in pulmonary hemodynamics, pulmonary and systemic pressures were measured and left pulmonary arterial flow
was measured by an ultrasonic Doppler flow probe. Variables were
measured during a 1- to 2-h control period and for 4 h after a small
bolus of isotonic saline saturated with nitric oxide gas (10 or 100%)
was instilled into the lung liquid. Control (saline) instillations
(n = 6) caused no change in any
variable over 6 h. Nitric oxide instillation significantly decreased
Jv and increased pulmonary blood flow;
these effects were sustained for 1-2 h. There was also a
significant but transient decrease in pulmonary arterial pressure. Thus
intrapulmonary nitric oxide causes a significant decrease in lung
liquid and is associated with a decrease in pulmonary vascular
resistance. In a separate series of experiments either amiloride or
benzamil, which blocks Na+
transport, was mixed into the lung liquid before nitric oxide instillation; still, there was a similar reduction in lung liquid production. Thus the reduction in lung liquid secretion caused by
nitric oxide does not appear to depend on apical
Na+ efflux.
pulmonary circulation; ion transport; birth transition; fetus
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