Journal of Applied Physiology
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J Appl Physiol 83: 1492-1498, 1997;
8750-7587/97 $5.00
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Vol. 83, Issue 5, 1492-1498, 1997

Adrenergic beta 1- and beta 1+2-receptor blockade suppress the natural killer cell response to head-up tilt in humans

M. Klokker, N. H. Secher, P. Madsen, M. Pedersen, and B. K. Pedersen

Departments of Infectious Diseases and Anesthesia, Copenhagen Muscle Research Center, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen N; and Danish Armed Forces Health Services, Jægersborg, DK-2820 Gentofte, Denmark

Received 22 May 1996; accepted in final form 26 June 1997.

Klokker, M., N. H. Secher, P. Madsen, M. Pedersen, and B. K. Pedersen. Adrenergic beta 1- and beta 1+2-receptor blockade suppress the natural killer cell response to head-up tilt in humans. J. Appl. Physiol. 83(5): 1492-1498, 1997.---To evaluate stress-induced changes in blood leukocytes with emphasis on the natural killer (NK) cells, eight male volunteers were followed during three trials of head-up tilt with adrenergic beta 1- (metoprolol) and beta 1+2- (propranolol) blockade and with saline (control) infusions. The beta 1- and beta 1+2-receptor blockade did not affect the appearance of presyncopal symptoms, but the head-up tilt induced a transient lymphocytosis that was abolished by beta 1+2-receptor blockade but not by beta 1-receptor blockade. Head-up tilt also resulted in delayed neutrophilia, which was insensitive to beta -receptor blockade. Lymphocyte subset analysis revealed that the head-up tilt resulted in a twofold increase in the percentage and absolute number of CD3-/CD16+ and CD3-/CD56+ NK cells in peripheral blood and that this increase was partially blocked by metoprolol and abolished by propranolol. The NK cell activity on a per NK cell basis did not change during head-up tilt, indicating that the cytotoxic capability of NK cells recruited to circulation is unchanged. The data suggest that the head-up tilt-induced lymphocytosis was due mainly to CD16+ and CD56+ NK cells and that their recruitment to the blood was inhibited by beta 1- and especially beta 1+2-receptor blockade. Thus stress-induced recruitment of lymphocytes, and of NK cells in particular, is mediated by epinephrine through activation of beta -receptors on the lymphocytes.

aviation medicine; catecholamines; gravity; leukocytes; lymphocytes; lymphocyte subsets; neutrophils; T cells

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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