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Vol. 83, Issue 5, 1438-1447, 1997
1 Department of Respiratory
Medicine,
Received 5 March 1997; accepted in final form 8 July 1997.
Murphy, K., D. R. Corfield, A. Guz, G. R. Fink, R. J. S. Wise, J. Harrison, and L. Adams. Cerebral areas associated with
motor control of speech in humans. J. Appl.
Physiol. 83(5): 1438-1447, 1997.
articulation; control of breathing; vocalization
We have defined
areas in the brain activated during speaking, utilizing positron
emission tomography. Six normal subjects continuously repeated the
phrase "Buy Bobby a poppy" (requiring minimal language
processing) in four ways: A) spoken aloud, B) mouthed silently,
C) without articulation, and
D) thought silently. Statistical
comparison of images from conditions A
with C and
B with
D highlighted areas associated with
articulation alone, because control of breathing for speech was
controlled for; we found bilateral activations in sensorimotor cortex
and cerebellum with right-sided activation in the thalamus/caudate nucleus. Contrasting images from conditions
A with B and
C with D highlighted areas associated with
the control of breathing for speech, vocalization, and hearing, because
articulation was controlled for; we found bilateral activations in
sensorimotor and motor cortex, close to but distinct from the
activations in the preceding contrast, together with activations in
thalamus, cerebellum, and supplementary motor area. In neither
subtraction was there activation in Broca's area. These results
emphasize the bilaterality of the cerebral control of "speaking"
without language processing.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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