Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1370-1382, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parker, J. C.
Right arrow Articles by Williams, S. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parker, J. C.
Right arrow Articles by Williams, S. G.

Journal of Applied Physiology
Vol. 83, No. 4, pp. 1370-1382, October 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

MODELING IN PHYSIOLOGY

Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions

James C. Parker1, Chris B. Cave1, Jeffrey L. Ardell1, Charles R. Hamm2, and Susan G. Williams3

Departments of 1 Physiology, 2 Pediatrics, and 3 Mathematics, University of South Alabama, Mobile, Alabama 36688

Received 29 January 1996; accepted in final form 21 April 1997.

Parker, James C., Chris B. Cave, Jeffrey L. Ardell, Charles R. Hamm, and Susan G. Williams. Vascular tree structure affects lung blood flow heterogeneity simulated in three dimensions. J. Appl. Physiol. 83(4): 1370-1382, 1997.---Pulmonary arterial tree structures related to blood flow heterogeneity were simulated by using a symmetrical, bifurcating model in three-dimensional space. The branch angle (Theta ), daughter-parent length ratio (rL), branch rotation angle (phi ), and branch fraction of parent flow (gamma ) for a single bifurcation were defined and repeated sequentially through 11 generations. With phi  fixed at 90°, tree structures were generated with Theta  between 60 and 90°, rL between 0.65 and 0.85, and an initial segment length of 5.6 cm and sectioned into 1-cm3 samples for analysis. Blood flow relative dispersions (RD%) between 52 and 42% and fractal dimensions (Ds) between 1.20 and 1.15 in 1-cm3 samples were observed even with equal branch flows. When gamma  not equal 0.5, RD% increased, but Ds either decreased with gravity bias of higher branch flows or increased with random assignment of higher flows. Blood flow gradients along gravity and centripetal vectors increased with biased flow assignment of higher flows, and blood flows correlated negatively with distance only when gamma  not equal  0.5. Thus a recursive branching vascular tree structure simulated Ds and RD% values for blood flow heterogeneity similar to those observed experimentally in the pulmonary circulation due to differences in the number of terminal arterioles per 1-cm3 sample, but blood flow gradients and a negative correlation of flows with distance required unequal partitioning of blood flows at branch points.

regional pulmonary blood flow; pulmonary circulation; gravity gradients; fractal analysis; relative dispersion; computer simulation; distance correlation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Marxen, J. G. Sled, L. X. Yu, C. Paget, and R. M. Henkelman
Comparing microsphere deposition and flow modeling in 3D vascular trees
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2136 - H2141.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. S. Burrowes, P. J. Hunter, and M. H. Tawhai
Anatomically based finite element models of the human pulmonary arterial and venous trees including supernumerary vessels
J Appl Physiol, August 1, 2005; 99(2): 731 - 738.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Physiol.Home page
R. Karch, F. Neumann, B. K. Podesser, M. Neumann, P. Szawlowski, and W. Schreiner
Fractal Properties of Perfusion Heterogeneity in Optimized Arterial Trees: A Model Study
J. Gen. Physiol., August 25, 2003; 122(3): 307 - 322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Marxen and R. M. Henkelman
Branching tree model with fractal vascular resistance explains fractal perfusion heterogeneity
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1848 - H1857.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Kitaoka, R. Takaki, and B. Suki
A three-dimensional model of the human airway tree
J Appl Physiol, December 1, 1999; 87(6): 2207 - 2217.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online