Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1291-1299, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Delp, M. D.
Right arrow Articles by Musch, T. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delp, M. D.
Right arrow Articles by Musch, T. I.

Journal of Applied Physiology
Vol. 83, No. 4, pp. 1291-1299, October 1997
EXERCISE AND MUSCLE

Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure

Michael D. Delp, Changping Duan, John P. Mattson, and Timothy I. Musch

Departments of Health and Kinesiology and of Medical Physiology, Texas A&M University, College Station, Texas 77843; Department of Surgery, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212; and Departments of Anatomy and Physiology and of Kinesiology, Kansas State University, Manhattan, Kansas 66506

Received 11 December 1996; accepted in final form 19 May 1997.

Delp, Michael D., Changping Duan, John P. Mattson, and Timothy I. Musch. Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure. J. Appl. Physiol. 83(4): 1291-1299, 1997.---One of the primary consequences of left ventricular dysfunction (LVD) after myocardial infarction is a decrement in exercise capacity. Several factors have been hypothesized to account for this decrement, including alterations in skeletal muscle metabolism and aerobic capacity. The purpose of this study was to determine whether LVD-induced alterations in skeletal muscle enzyme activities, fiber composition, and fiber size are 1) generalized in muscles or specific to muscles composed primarily of a given fiber type and 2) related to the severity of the LVD. Female Wistar rats were divided into three groups: sham-operated controls (n = 13) and rats with moderate (n = 10) and severe (n = 7) LVD. LVD was surgically induced by ligating the left main coronary artery and resulted in elevations (P < 0.05) in left ventricular end-diastolic pressure (sham, 5 ± 1 mmHg; moderate LVD, 11 ± 1 mmHg; severe LVD, 25 ± 1 mmHg). Moderate LVD decreased the activities of phosphofructokinase (PFK) and citrate synthase in one muscle composed of type IIB fibers but did not modify fiber composition or size of any muscle studied. However, severe LVD diminished the activity of enzymes involved in terminal and beta -oxidation in muscles composed primarily of type I fibers, type IIA fibers, and type IIB fibers. In addition, severe LVD induced a reduction in the activity of PFK in type IIB muscle, a 10% reduction in the percentage of type IID/X fibers, and a corresponding increase in the portion of type IIB fibers. Atrophy of type I fibers, type IIA fibers, and/or type IIB fibers occurred in soleus and plantaris muscles of rats with severe LVD. These data indicate that rats with severe LVD after myocardial infarction exhibit 1) decrements in mitochondrial enzyme activities independent of muscle fiber composition, 2) a reduction in PFK activity in type IIB muscle, 3) transformation of type IID/X to type IIB fibers, and 4) atrophy of type I, IIA, and IIB fibers.

3-hydroxyacyl-CoA dehydrogenase; lactate dehydrogenase; malate dehydrogenase

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. A. Sperandio, A. Borghi-Silva, A. Barroco, L. E. Nery, D. R. Almeida, and J. A. Neder
Microvascular oxygen delivery-to-utilization mismatch at the onset of heavy-intensity exercise in optimally treated patients with CHF
Am J Physiol Heart Circ Physiol, November 1, 2009; 297(5): H1720 - H1728.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
K. Abozguia, T. T. Phan, G. N. Shivu, A. R. Maher, I. Ahmed, A. Wagenmakers, and M. P. Frenneaux
Reduced in vivo skeletal muscle oxygen consumption in patients with chronic heart failure--A study using Near Infrared Spectrophotometry (NIRS)
Eur J Heart Fail, July 1, 2008; 10(7): 652 - 657.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. B. Nunes, M. Tonetto, N. Machado, M. Chazan, T. G. Heck, A. B. G. Veiga, and P. Dall'Ago
Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure rats
J Appl Physiol, June 1, 2008; 104(6): 1641 - 1647.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Lawler, H.-B. Kwak, W. Song, and J. L. Parker
Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1756 - R1763.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Walsh, R. B. Hooks, J. E. Hornyak, L. G. Koch, S. L. Britton, and M. C. Hogan
Enhanced mitochondrial sensitivity to creatine in rats bred for high aerobic capacity
J Appl Physiol, June 1, 2006; 100(6): 1765 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. A. Barash, L. Mathew, M. Lahey, M. L. Greaser, and R. L. Lieber
Muscle LIM protein plays both structural and functional roles in skeletal muscle
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1312 - C1320.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. A. Smith, J. H. Mitchell, R. H. Naseem, and M. G. Garry
Mechanoreflex Mediates the Exaggerated Exercise Pressor Reflex in Heart Failure
Circulation, October 11, 2005; 112(15): 2293 - 2300.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. S. Supinski and L. A. Callahan
Diaphragmatic free radical generation increases in an animal model of heart failure
J Appl Physiol, September 1, 2005; 99(3): 1078 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. J. Barr, H. J. Green, D. S. Lounsbury, J. W. E. Rush, and J. Ouyang
Na+-K+-ATPase properties in rat heart and skeletal muscle 3 mo after coronary artery ligation
J Appl Physiol, August 1, 2005; 99(2): 656 - 664.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. A. Smith, M. A. Williams, J. H. Mitchell, P. P.A. Mammen, and M. G. Garry
The Capsaicin-Sensitive Afferent Neuron in Skeletal Muscle Is Abnormal in Heart Failure
Circulation, April 26, 2005; 111(16): 2056 - 2065.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. M. Karim, A. Y. Rhee, A. M. Given, M. D. Faulx, B. D. Hoit, and F. V. Brozovich
Vascular Reactivity in Heart Failure: Role of Myosin Light Chain Phosphatase
Circ. Res., September 17, 2004; 95(6): 612 - 618.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole
Effects of chronic heart failure in rats on the recovery of microvascular PO2 after contractions in muscles of opposing fibre type
Exp Physiol, July 1, 2004; 89(4): 473 - 485.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. G. Mayhan, H. Sun, J. F. Mayhan, and K. P. Patel
Influence of exercise on dilatation of the basilar artery during diabetes mellitus
J Appl Physiol, May 1, 2004; 96(5): 1730 - 1737.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. McDonough, B. J. Behnke, T. I. Musch, and D. C. Poole
Recovery of microvascular PO2 during the exercise off-transient in muscles of different fiber type
J Appl Physiol, March 1, 2004; 96(3): 1039 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. A. Smith, P. P.A. Mammen, J. H. Mitchell, and M. G. Garry
Role of the Exercise Pressor Reflex in Rats With Dilated Cardiomyopathy
Circulation, September 2, 2003; 108(9): 1126 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. E. Richardson, C. A. Kindig, T. I. Musch, and D. C. Poole
Effects of chronic heart failure on skeletal muscle capillary hemodynamics at rest and during contractions
J Appl Physiol, September 1, 2003; 95(3): 1055 - 1062.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Helwig, K. M. Schreurs, J. Hansen, K. S. Hageman, M. G. Zbreski, R. M. McAllister, K. E. Mitchell, and T. I. Musch
Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure
J Appl Physiol, June 1, 2003; 94(6): 2225 - 2236.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E.R. Diederich, B.J. Behnke, P. McDonough, C.A. Kindig, T.J. Barstow, D.C. Poole, and T.I. Musch
Dynamics of microvascular oxygen partial pressure in contracting skeletal muscle of rats with chronic heart failure
Cardiovasc Res, December 1, 2002; 56(3): 479 - 486.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. I. Musch, S. Wolfram, K. S. Hageman, and J. G. Pickar
Skeletal muscle ouabain binding sites are reduced in rats with chronic heart failure
J Appl Physiol, June 1, 2002; 92(6): 2326 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. E. Spangenburg, S. J. Lees, J. S. Otis, T. I. Musch, R. J. Talmadge, and J. H. Williams
Effects of moderate heart failure and functional overload on rat plantaris muscle
J Appl Physiol, January 1, 2002; 92(1): 18 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. G. Aschenbach, G. L. Brower, R. J. Talmadge, J. L. Dobson, and L. B. Gladden
Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R176 - R186.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. De Sousa, V. Veksler, X. Bigard, P. Mateo, and R. Ventura-Clapier
Heart Failure Affects Mitochondrial but Not Myofibrillar Intrinsic Properties of Skeletal Muscle
Circulation, October 10, 2000; 102(15): 1847 - 1853.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. P. Thomas and O. Hudlicka
Arteriolar reactivity and capillarization in chronically stimulated rat limb skeletal muscle post-MI
J Appl Physiol, December 1, 1999; 87(6): 2259 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. D. Symons, C. L. Stebbins, and T. I. Musch
Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats
J Appl Physiol, August 1, 1999; 87(2): 574 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Kindig, T. I. Musch, R. J. Basaraba, and D. C. Poole
Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure
J Appl Physiol, August 1, 1999; 87(2): 652 - 660.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. K. Shoemaker, A. R. Kunselman, D. H. Silber, and L. I. Sinoway
Maintained exercise pressor response in heart failure
J Appl Physiol, November 1, 1998; 85(5): 1793 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. P. Thomas, O. Hudlicka, M. D. Brown, and D. Deveci
Alterations in small arterioles precede changes in limb skeletal muscle after myocardial infarction
Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1032 - H1039.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. K. Lunde, A. J. Dahlstedt, J. D. Bruton, J. Lannergren, P. Thoren, O. M. Sejersted, and H. Westerblad
Contraction and Intracellular Ca2+ Handling in Isolated Skeletal Muscle of Rats With Congestive Heart Failure
Circ. Res., June 22, 2001; 88(12): 1299 - 1305.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online