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J Appl Physiol 83: 1270-1275, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 4, pp. 1270-1275, October 1997
EXERCISE AND MUSCLE

Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats

Daniel R. Marsh, David S. Criswell, James A. Carson, and Frank W. Booth

Department of Integrative Biology, University of Texas Medical School, Houston, Texas 77030

Received 27 January 1997; accepted in final form 16 May 1997.

Marsh, Daniel R., David S. Criswell, James A. Carson, and Frank W. Booth. Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats. J. Appl. Physiol. 83(4): 1270-1275, 1997.---Myogenic factor mRNA expression was examined during muscle regeneration after bupivacaine injection in Fischer 344/Brown Norway F1 rats aged 3, 18, and 31 mo of age (young, adult, and old, respectively). Mass of the tibialis anterior muscle in the young rats had recovered to control values by 21 days postbupivacaine injection but in adult and old rats remained 40% less than that of contralateral controls at 21 and 28 days of recovery. During muscle regeneration, myogenin mRNA was significantly increased in muscles of young, adult, and old rats 5 days after bupivacaine injection. Subsequently, myogenin mRNA levels in young rat muscle decreased to postinjection control values by day 21 but did not return to control values in 28-day regenerating muscles of adult and old rats. The expression of MyoD mRNA was also increased in muscles at day 5 of regeneration in young, adult, and old rats, decreased to control levels by day 14 in young and adult rats, and remained elevated in the old rats for 28 days. In summary, either a diminished ability to downregulate myogenin and MyoD mRNAs in regenerating muscle occurs in old rat muscles, or the continuing myogenic effort includes elevated expression of these mRNAs.

aging; bupivacaine injection; muscle mass; recovery

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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