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Departments of 1 Pediatrics and 2 Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, Indiana 46223
Received 5 March 1997; accepted in final form 19 June 1997.
Shen, X., S. J. Gunst, and R. S. Tepper. Effect of
tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J. Appl. Physiol.
83(4): 1202-1208, 1997.
We evaluated the effects of the rate and
volume of tidal ventilation on airway resistance (Raw) during
intravenous methacholine (MCh) challenge in mechanically ventilated
rabbits. Five rabbits were challenged at tidal volumes of 5, 10, and 20 ml/kg at a frequency of 15 breaths/min and also under static conditions
(0 ml/kg tidal volume). Four rabbits were subjected to MCh challenge at
frequencies of 6 and 30 breaths/min with a tidal volume of 10 ml/kg and
also under static conditions. In both groups, the increase in Raw with MCh challenge was significantly greater under static conditions than
during tidal ventilation at any frequency or volume. Increases in the
volume or frequency of tidal ventilation resulted in significant decreases in Raw in response to MCh. We conclude that tidal breathing suppresses airway responsiveness in rabbits in vivo. The suppression of
narrowing in response to MCh increases as the magnitude of the volume
or the frequency of the tidal oscillations is increased. Our findings
suggest that the effect of lung volume changes on airway responsiveness
in vivo is primarily related to the stretch of airway smooth muscle.
airway narrowing; tidal breathing; airway smooth muscle
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