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1 Laboratoire de Neurologie et
Physiologie du Développement,
Received 2 April 1996; accepted in final form 5 June 1997.
Nsegbe, Elise, Guy Vardon, Pierre Perruchet, and Jorge
Gallego. Classic conditioning of the ventilatory responses in rats. J. Appl. Physiol. 83(4):
1174-1183, 1997.
control of breathing; carbon dioxide
Recent authors have stressed the role of
conditioning in the control of breathing, but experimental evidence of
this role is still sparse and contradictory. To establish that classic
conditioning of the ventilatory responses can occur in rats, we
performed a controlled experiment in which a 1-min tone
[conditioned stimulus (CS)] was paired with a hypercapnic stimulus [8.5% CO2,
unconditioned stimulus (US)]. The experimental group
(n = 9) received five paired CS-US
presentations, followed by one CS alone to test conditioning. This
sequence was repeated six times. The control group
(n = 7) received the same number of CS
and US, but each US was delivered 3 min after the CS. We observed that
after the CS alone, breath duration was significantly longer in the
experimental than in the control group and mean ventilation was
significantly lower, thus showing inhibitory conditioning. This
conditioning may have resulted from the association between the CS and
the inhibitory and aversive effects of
CO2. The present results confirmed
the high sensitivity of the respiratory controller to conditioning
processes.
0161-7567/97 $5.00
Copyright © 1997 the American Physiological Society
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