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J Appl Physiol 83: 1076-1082, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 4, pp. 1076-1082, October 1997
EXERCISE AND MUSCLE

Skeletal troponin I as a marker of exercise-induced muscle damage

Stephan Sorichter1, Johannes Mair1, Arnold Koller2, Walter Gebert2, Daniel Rama3, Charles Calzolari3, Erika Artner-Dworzak1, and Bernd Puschendorf1

Departments of 1 Medical Chemistry and Biochemistry and of 2 Sports Medicine, University of Innsbruck Medical School, A-6020 Innsbruck, Austria; and 3 Sanofi Research Centre Montpellier, F-34184 Montpellier, France

Received 5 December 1996; accepted in final form 19 May 1997.

Sorichter, Stephan, Johannes Mair, Arnold Koller, Walter Gebert, Daniel Rama, Charles Calzolari, Erika Artner-Dworzak, and Bernd Puschendorf. Skeletal troponin I as a marker of exercise-induced muscle damage. J. Appl. Physiol. 83(4): 1076-1082, 1997.---The utility of skeletal troponin I (sTnI) as a plasma marker of skeletal muscle damage after exercise was compared against creatine kinase (CK), myoglobin (Mb), and myosin heavy chain (MHC) fragments. These markers were serially measured in normal physical education teacher trainees after four different exercise regimens: 20 min of level or downhill (16% decline) running (intensity: 70% maximal O2 uptake), high-force eccentric contractions (70 repetitions), or high-force isokinetic concentric contractions of the quadriceps group (40 repetitions). Eccentrically biased exercise (downhill running and eccentric contractions) promoted greater increases in all parameters. The highest plasma concentration were found after downhill running {median peaks: 309 U/l CK concentration ([CK])}, 466 µg/l Mb concentration ([Mb]), 1,021 µU/l MHC concentration ([MHC]), and 27.3 µg/l sTnI concentration ([sTnI]). Level running produced a moderate response (median peaks: 178 U/l [CK], 98 µg/l [Mb], 501 µU/l [MHC], and 6.6 µg/l [sTnI]), whereas the concentric contraction protocol did not elicit significant changes in any of the markers assayed. sTnI increased and peaked in parallel to CK and stayed elevated (>2.2 µg/l) for at least 1-2 days after exercise. In contrast to MHC, sTnI is an initial, specific marker of exercise-induced muscle injury, which may be partly explained by their different intracellular compartmentation with essentially no (MHC <0.1%) or a small soluble pool (sTnI: median 3.4%).

myosin heavy chain; creatine kinase; myoglobin

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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