Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 1076-1082, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sorichter, S.
Right arrow Articles by Puschendorf, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sorichter, S.
Right arrow Articles by Puschendorf, B.

Journal of Applied Physiology
Vol. 83, No. 4, pp. 1076-1082, October 1997
EXERCISE AND MUSCLE

Skeletal troponin I as a marker of exercise-induced muscle damage

Stephan Sorichter1, Johannes Mair1, Arnold Koller2, Walter Gebert2, Daniel Rama3, Charles Calzolari3, Erika Artner-Dworzak1, and Bernd Puschendorf1

Departments of 1 Medical Chemistry and Biochemistry and of 2 Sports Medicine, University of Innsbruck Medical School, A-6020 Innsbruck, Austria; and 3 Sanofi Research Centre Montpellier, F-34184 Montpellier, France

Received 5 December 1996; accepted in final form 19 May 1997.

Sorichter, Stephan, Johannes Mair, Arnold Koller, Walter Gebert, Daniel Rama, Charles Calzolari, Erika Artner-Dworzak, and Bernd Puschendorf. Skeletal troponin I as a marker of exercise-induced muscle damage. J. Appl. Physiol. 83(4): 1076-1082, 1997.---The utility of skeletal troponin I (sTnI) as a plasma marker of skeletal muscle damage after exercise was compared against creatine kinase (CK), myoglobin (Mb), and myosin heavy chain (MHC) fragments. These markers were serially measured in normal physical education teacher trainees after four different exercise regimens: 20 min of level or downhill (16% decline) running (intensity: 70% maximal O2 uptake), high-force eccentric contractions (70 repetitions), or high-force isokinetic concentric contractions of the quadriceps group (40 repetitions). Eccentrically biased exercise (downhill running and eccentric contractions) promoted greater increases in all parameters. The highest plasma concentration were found after downhill running {median peaks: 309 U/l CK concentration ([CK])}, 466 µg/l Mb concentration ([Mb]), 1,021 µU/l MHC concentration ([MHC]), and 27.3 µg/l sTnI concentration ([sTnI]). Level running produced a moderate response (median peaks: 178 U/l [CK], 98 µg/l [Mb], 501 µU/l [MHC], and 6.6 µg/l [sTnI]), whereas the concentric contraction protocol did not elicit significant changes in any of the markers assayed. sTnI increased and peaked in parallel to CK and stayed elevated (>2.2 µg/l) for at least 1-2 days after exercise. In contrast to MHC, sTnI is an initial, specific marker of exercise-induced muscle injury, which may be partly explained by their different intracellular compartmentation with essentially no (MHC <0.1%) or a small soluble pool (sTnI: median 3.4%).

myosin heavy chain; creatine kinase; myoglobin

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 Br. J. Sports. Med.Home page
A W Nichols
Sports medicine clinical trial research publications in academic medical journals between 1996 and 2005: an audit of the PubMed MEDLINE database
Br. J. Sports Med., November 1, 2008; 42(11): 909 - 912.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
M Guerrero, M Guiu-Comadevall, J A Cadefau, J Parra, R Balius, A Estruch, G Rodas, J L Bedini, and R Cusso
Fast and slow myosins as markers of muscle injury
Br. J. Sports Med., July 1, 2008; 42(7): 581 - 584.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Broholm, O. H. Mortensen, S. Nielsen, T. Akerstrom, A. Zankari, B. Dahl, and B. K. Pedersen
Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle
J. Physiol., April 15, 2008; 586(8): 2195 - 2201.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A. Martinez Amat, J. A. Marchal Corrales, F. Rodriguez Serrano, H. Boulaiz, J. C. Prados Salazar, F. Hita Contreras, O. Caba Perez, E. Carrillo Delgado, I. Martin, and A. Aranega Jimenez
Role of {alpha}-actin in muscle damage of injured athletes in comparison with traditional markers
Br. J. Sports Med., July 1, 2007; 41(7): 442 - 446.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
N D Gill, C M Beaven, and C Cook
Effectiveness of post-match recovery strategies in rugby players.
Br. J. Sports Med., March 1, 2006; 40(3): 260 - 263.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
S. Sheng, D. Chen, and J. E. Van Eyk
Multidimensional Liquid Chromatography Separation of Intact Proteins by Chromatographic Focusing and Reversed Phase of the Human Serum Proteome: Optimization and Protein Database
Mol. Cell. Proteomics, January 1, 2006; 5(1): 26 - 34.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A Martinez-Amat, H Boulaiz, J Prados, J A Marchal, P Padial Puche, O Caba, F Rodriguez-Serrano, and A Aranega
Release of {alpha}-actin into serum after skeletal muscle damage
Br. J. Sports Med., November 1, 2005; 39(11): 830 - 834.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Kano, D. J. Padilla, B. J. Behnke, K. S. Hageman, T. I. Musch, and D. C. Poole
Effects of eccentric exercise on microcirculation and microvascular oxygen pressures in rat spinotrapezius muscle
J Appl Physiol, October 1, 2005; 99(4): 1516 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. A. Simpson, R. Labugger, C. Collier, R. J. Brison, S. Iscoe, and J. E. Van Eyk
Fast and Slow Skeletal Troponin I in Serum from Patients with Various Skeletal Muscle Disorders: A Pilot Study
Clin. Chem., June 1, 2005; 51(6): 966 - 972.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Akerstrom, A. Steensberg, P. Keller, C. Keller, M. Penkowa, and B. K. Pedersen
Exercise induces interleukin-8 expression in human skeletal muscle
J. Physiol., March 1, 2005; 563(2): 507 - 516.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Simpson, J. Van Eyk, and S. Iscoe
Respiratory muscle injury, fatigue and serum skeletal troponin I in rat
J. Physiol., February 1, 2004; 554(3): 891 - 903.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. A. Simpson, R. Labugger, G. G. Hesketh, C. D'Arsigny, D. O'Donnell, N. Matsumoto, C. P. Collier, S. Iscoe, and J. E. Van Eyk
Differential Detection of Skeletal Troponin I Isoforms in Serum of a Patient with Rhabdomyolysis: Markers of Muscle Injury?
Clin. Chem., July 1, 2002; 48(7): 1112 - 1114.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. M. Bamman, J. R. Shipp, J. Jiang, B. A. Gower, G. R. Hunter, A. Goodman, C. L. McLafferty Jr., and R. J. Urban
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans
Am J Physiol Endocrinol Metab, March 1, 2001; 280(3): E383 - E390.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
C. G. Guglielmo, T. Piersma, and T. D. Williams
A sport-physiological perspective on bird migration: evidence for flight-induced muscle damage
J. Exp. Biol., January 8, 2001; 204(15): 2683 - 2690.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Simpson, J. E. van Eyk, and S. Iscoe
Hypoxemia-induced modification of troponin I and T in canine diaphragm
J Appl Physiol, February 1, 2000; 88(2): 753 - 760.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Avela, H. Kyrolainen, P. V. Komi, and D. Rama
Reduced reflex sensitivity persists several days after long-lasting stretch-shortening cycle exercise
J Appl Physiol, April 1, 1999; 86(4): 1292 - 1300.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online