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J Appl Physiol 83: 1062-1067, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 4, pp. 1062-1067, October 1997
EXERCISE AND MUSCLE

Corticosteroid effects on isotonic contractile properties of rat diaphragm muscle

Roland H. H. Van Balkom1, Wen-Zhi Zhan2, Y. S. Prakash2, P. N. Richard Dekhuijzen1, and Gary C. Sieck2,3

1 Department of Pulmonary Diseases, University Hospital Nijmegen, Nijmegen 6500 HB, The Netherlands; and Departments of 2 Anesthesiology, and 3 Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905

Received 16 December 1996; accepted in final form 8 May 1997.

Van Balkom, Roland H. H., Wen-Zhi Zhan, Y. S. Prakash, P. N. Richard Dekhuijzen, and Gary C. Sieck. Corticosteroid effects on isotonic contractile properties of rat diaphragm muscle. J. Appl. Physiol. 83(4): 1062-1067, 1997.---The effects of corticosteroids (CS) on diaphragm muscle (Diam) fiber morphology and contractile properties were evaluated in three groups of rats: controls (Ctl), surgical sham and weight-matched controls (Sham), and CS-treated (6 mg · kg-1 · day-1 prednisolone at 2.5 ml/h for 3 wk). In the CS-treated Diam, there was a selective atrophy of type IIx and IIb fibers, compared with a generalized atrophy of all fibers in the Sham group. Maximum isometric force was reduced by 20% in the CS group compared with both Ctl and Sham. Maximum shortening velocity in the CS Diam was slowed by ~20% compared with Ctl and Sham. Peak power output of the CS Diam was only 60% of Ctl and 70% of Sham. Endurance to repeated isotonic contractions improved in the CS-treated Diam compared with Ctl. We conclude that the atrophy of type IIx and IIb fibers in the Diam can only partially account for the CS-induced changes in isotonic contractile properties. Other factors such as reduced myofibrillar density or altered cross-bridge cycling kinetics are also likely to contribute to the effects of CS treatment.

prednisolone; skeletal muscle; fiber type; shortening velocity; fatigue; endurance

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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