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Section of Applied Physiology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110
Received 7 January 1997; accepted in final form 9 June 1997.
Hickner, R. C., J. S. Fisher, P. A. Hansen, S. B. Racette,
C. M. Mier, M. J. Turner, and J. O. Holloszy. Muscle glycogen accumulation after endurance exercise in trained and untrained individuals. J. Appl. Physiol. 83(3):
897-903, 1997.
Muscle glycogen accumulation was determined in six
trained cyclists (Trn) and six untrained subjects (UT) at 6 and either
48 or 72 h after 2 h of cycling exercise at ~75% peak
O2 uptake
(
O2 peak), which terminated with five 1-min sprints. Subjects ate 10 g
carbohydrate · kg
1 · day1
for 48-72 h postexercise. Muscle glycogen accumulation averaged 71 ± 9 (SE) mmol/kg (Trn) and 31 ± 9 mmol/kg (UT) during the first 6 h postexercise (P < 0.01) and 79 ± 22 mmol/kg (Trn) and 60 ± 9 mmol/kg (UT) between 6 and 48 or 72 h postexercise (not significant). Muscle glycogen
concentration was 164 ± 21 mmol/kg (Trn) and 99 ± 16 mmol/kg
(UT) 48-72 h postexercise (P < 0.05). Muscle GLUT-4 content immediately postexercise was threefold
higher in Trn than in UT (P < 0.05)
and correlated with glycogen accumulation rates (r = 0.66, P < 0.05). Glycogen synthase in the
active I form was 2.5 ± 0.5, 3.3 ± 0.5, and 1.0 ± 0.3 µmol · g1 · min1
in Trn at 0, 6, and 48 or 72 h postexercise, respectively;
corresponding values were 1.2 ± 0.3, 2.7 ± 0.5, and 1.6 ± 0.3 µmol · g1 · min1
in UT (P < 0.05 at 0 h). Plasma
insulin and plasma C-peptide area under the curve were lower in Trn
than in UT over the first 6 h postexercise
(P < 0.05). Plasma creatine kinase
concentrations were 125 ± 25 IU/l (Trn) and 91 ± 9 IU/l (UT)
preexercise and 112 ± 14 IU/l (Trn) and 144 ± 22 IU/l
(UT; P < 0.05 vs.
preexercise) at 48-72 h postexercise (normal: 30-200 IU/l).
We conclude that endurance exercise training results in an increased
ability to accumulate muscle glycogen after exercise.
fiber type; GLUT-4; glycogen synthase; glycogen supercompensation
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