Journal of Applied Physiology
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J Appl Physiol 83: 845-850, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 3, pp. 845-850, September 1997
EXERCISE AND MUSCLE

Modulation of NK cell cytolytic activity by macrophages in chronically exercise-stressed mice

Sally E. Blank1, T. Bucky Jones1, Eric G. Lee1, C. Jayne Brahler1, Randle M. Gallucci2, Marne L. Fox1, and Gary G. Meadows2

Departments of 1 Kinesiology and 2 Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164-1410

Received 8 January 1997; accepted in final form 6 May 1997.

Blank, Sally E., T. Bucky Jones, Eric G. Lee, C. Jayne Brahler, Randle M. Gallucci, Marne L. Fox, and Gary G. Meadows. Modulation of NK cell cytolytic activity by macrophages in chronically exercise-stressed mice. J. Appl. Physiol. 83(3): 845-850, 1997.---This study was designed to investigate the effects of moderate-intensity endurance training on basal natural killer (NK) cell cytolytic activity in murine splenocytes that were enriched for 1) NK1.1+ cells or 2) macrophages and NK1.1+ cells. Mice were assigned to sedentary (Sed), treadmill control (TM), or treadmill-trained (Trn) groups. Splenocyte number, the percentages of NK1.1+, large granular lymphocytes (NK1.1+, LGL-1+), and other subpopulations did not change in Trn mice. Approximately 70% of cells enriched for NK1.1+ expressed this surface antigen. Lytic units (LU) expressed per LGL-1+ cell were significantly lower in Trn [83.9 ± 3.2 (SE)] compared with Sed (109.5 ± 7.5) and TM (101.3 ± 6.4) groups. When macrophages remained in the in vitro assay, LU per LGL-1+ cell did not differ across groups. The results indicate that highly enriched NK1.1+ cells from Trn mice had lower NK cell activity compared with Sed mice. No differences in NK cell activity were observed when cells were enriched for NK1.1+ cells and macrophages. These findings support the hypothesis that macrophage modulation of NK cells may be one mechanism contributing to augmented basal NK cell activity in endurance-trained individuals.

endurance training; juxtacrine and paracrine regulation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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