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J Appl Physiol 83: 817-823, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 3, pp. 817-823, September 1997
EXERCISE AND MUSCLE

Contraction-induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E

Jack H. Van Der Meulen1, Anne McArdle2, Malcolm J. Jackson2, and John A. Faulkner1

1 Institute of Gerontology, University of Michigan, Ann Arbor, Michigan 48109-2007; and 2 Muscle Research Centre, Department of Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom

Received 4 March 1996; accepted in final form 6 May 1997.

Van der Meulen, Jack H., Anne McArdle, Malcolm J. Jackson, and John A. Faulkner. Contraction-induced injury to the extensor digitorum longus muscles of rats: the role of vitamin E. J. Appl. Physiol. 83(3): 817-823, 1997.---Three days after a protocol of 225 pliometric (lengthening) contractions was administered to in situ extensor digitorum longus muscles of rats, the force deficit was 64 ± 7% and the percentage of damaged muscle fibers was 38 ± 5% of the control values. We then tested the hypothesis that at 3 h and 3 days after the protocol an elevation in the muscle vitamin E content would decrease the force deficit, the percentage of damaged muscle fibers, and the serum activities of creatine kinase and pyruvate kinase. The 5-8 days of intravenous injections of alpha -tocopherol increased muscle vitamin E content threefold compared with vehicle (ethanol)-treated rats. Despite the difference in vitamin E content, the force deficit and number of damaged fibers were not different. After the contraction protocol, the serum creatine kinase and pyruvate kinase activities of the vehicle-treated rats increased fourfold at 3 h and twofold at 3 days, whereas the vitamin E-treated rats showed no change. We conclude that vitamin E treatment did not ameliorate either the induction of the injury or the more severe secondary injury at 3 days. Despite the absence of evidence for an antioxidant function, the lack of any increase in serum enzyme activities for vitamin E-treated rats at 3 h and 3 days supported a role for vitamin E in the prevention of enzyme loss after muscle damage.

pliometric contractions; muscle damage; serum creatine kinase activity; serum pyruvate kinase activity; eccentric exercise

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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