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1 Akademisch Ziekenhuis, Vrije Universiteit Brussel, 1090 Brussels, Belgium; 2 Karolinska Institute, S-17177 Stockholm, Sweden; 3 Department of Medicine, University of California San Diego, La Jolla, California 92093-0931; 4 Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070 Brussels, Belgium
Received 23 December 1996; accepted in final form 7 May 1997.
Verbanck, Sylvia, Hans Larsson, Dag Linnarsson, G. Kim
Prisk, John B. West, and Manuel Paiva. Pulmonary tissue volume, cardiac output and diffusing capacity in sustained microgravity. J. Appl. Physiol. 83(3): 810-816, 1997.
In microgravity (µG) humans have marked changes in body
fluids, with a combination of an overall fluid loss and a
redistribution of fluids in the cranial direction. We investigated
whether interstitial pulmonary edema develops as a result of a headward
fluid shift or whether pulmonary tissue fluid volume is reduced as a
result of the overall loss of body fluid. We measured pulmonary tissue
volume (Vti), capillary blood flow, and diffusing capacity in four
subjects before, during, and after 10 days of exposure to µG during
spaceflight. Measurements were made by rebreathing a gas mixture
containing small amounts of acetylene, carbon monoxide, and argon.
Measurements made early in flight in two subjects showed no change in
Vti despite large increases in stroke volume (40%) and diffusing
capacity (13%) consistent with increased pulmonary capillary blood
volume. Late in-flight measurements in four subjects showed a 25%
reduction in Vti compared with preflight controls
(P < 0.001). There was a
concomittant reduction in stroke volume, to the extent that it was no
longer significantly different from preflight control. Diffusing
capacity remained elevated (11%; P < 0.05) late in flight. These findings suggest that, despite
increased pulmonary perfusion and pulmonary capillary blood volume,
interstitial pulmonary edema does not result from exposure to µG.
spaceflight; zero gravity; acetylene rebreathing experiments
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