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J Appl Physiol 83: 810-816, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 3, pp. 810-816, September 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Pulmonary tissue volume, cardiac output, and diffusing capacity in sustained microgravity

Sylvia Verbanck1, Hans Larsson2, Dag Linnarsson2, G. Kim Prisk3, John B. West3, and Manuel Paiva4

1 Akademisch Ziekenhuis, Vrije Universiteit Brussel, 1090 Brussels, Belgium; 2 Karolinska Institute, S-17177 Stockholm, Sweden; 3 Department of Medicine, University of California San Diego, La Jolla, California 92093-0931; 4 Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070 Brussels, Belgium

Received 23 December 1996; accepted in final form 7 May 1997.

Verbanck, Sylvia, Hans Larsson, Dag Linnarsson, G. Kim Prisk, John B. West, and Manuel Paiva. Pulmonary tissue volume, cardiac output and diffusing capacity in sustained microgravity. J. Appl. Physiol. 83(3): 810-816, 1997.---In microgravity (µG) humans have marked changes in body fluids, with a combination of an overall fluid loss and a redistribution of fluids in the cranial direction. We investigated whether interstitial pulmonary edema develops as a result of a headward fluid shift or whether pulmonary tissue fluid volume is reduced as a result of the overall loss of body fluid. We measured pulmonary tissue volume (Vti), capillary blood flow, and diffusing capacity in four subjects before, during, and after 10 days of exposure to µG during spaceflight. Measurements were made by rebreathing a gas mixture containing small amounts of acetylene, carbon monoxide, and argon. Measurements made early in flight in two subjects showed no change in Vti despite large increases in stroke volume (40%) and diffusing capacity (13%) consistent with increased pulmonary capillary blood volume. Late in-flight measurements in four subjects showed a 25% reduction in Vti compared with preflight controls (P < 0.001). There was a concomittant reduction in stroke volume, to the extent that it was no longer significantly different from preflight control. Diffusing capacity remained elevated (11%; P < 0.05) late in flight. These findings suggest that, despite increased pulmonary perfusion and pulmonary capillary blood volume, interstitial pulmonary edema does not result from exposure to µG.

spaceflight; zero gravity; acetylene rebreathing experiments

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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