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J Appl Physiol 83: 792-799, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 3, pp. 792-799, September 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

RTN TRH causes prolonged respiratory stimulation

Carlos L. Cream, Aihua Li, and Eugene E. Nattie

Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756-0001

Received 6 March 1997; accepted in final form 30 April 1997.

Cream, Carlos L., Aihua Li, and Eugene E. Nattie. RTN TRH causes prolonged respiratory stimulation. J. Appl. Physiol. 83(3): 792-799, 1997.---We injected thyrotropin-releasing hormone (TRH; 10 nl; 0.25, 0.5, 1.0, or 10 mM), its inactive free acid form (TRHOH; 1 mM), or a metabolite with low TRH-receptor binding affinity, histidine-proline diketopiperazine (cHP; 1 mM), into the retrotrapezoid nucleus of anesthetized rats. Injection location was verified by anatomic analysis. Lower doses (0.25-0.5 mM) significantly increased both the product of integrated phrenic amplitude and frequency (<LIM><OP>∫</OP></LIM>Phr · f) and f for 20-30 min compared with artificial cerebrospinal fluid control injections. Higher doses (1.0-10 mM) produced greater and long-lasting stimulation of <LIM><OP>∫</OP></LIM>Phr · f, <LIM><OP>∫</OP></LIM>Phr, and f and of blood pressure. This stimulation reached values 150% of baseline and durations of 270 min after a single injection. TRHOH (1 mM ) or cHP (1 mM) had no effect on <LIM><OP>∫</OP></LIM>Phr but increased f, as did 1 mM TRH. We conclude that TRH has a very powerful stimulatory effect in the retrotrapezoid nucleus region on <LIM><OP>∫</OP></LIM>Phr · f, with the <LIM><OP>∫</OP></LIM>Phr response seemingly specific for TRH receptors. Similar responses of f to TRHOH and cHP suggest it may be nonspecific.

control of breathing; ventrolateral medulla; thyrotropin-releasing hormone free acid; histidine-proline diketopiperazine; blood pressure; respiratory regulation; retrotrapezoid nucleus

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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