| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Physiology and Biophysics and of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202
Received 11 February 1997; accepted in final form 6 May 1997.
Shen, X., M. F. Wu, R. S. Tepper, and S. J. Gunst. Mechanisms for the mechanical response of
airway smooth muscle to length oscillation. J. Appl.
Physiol. 83(3): 731-738, 1997.
Airway smooth
muscle tone in vitro is profoundly affected by oscillations in muscle
length, suggesting that the effects of lung volume changes on airway
tone result from direct effects of stretch on the airway smooth muscle.
We analyzed the effect of length oscillation on active force and
length-force hysteresis in canine tracheal smooth muscle at different
oscillation rates and amplitudes during contraction with acetylcholine.
During the shortening phase of the length oscillation cycle, the active
force generated by the smooth muscle decreased markedly below the
isometric force but returned to isometric force as the muscle was
lengthened. Results indicate that at rates comparable to those during
tidal breathing, active shortening and yielding of contractile elements
contributes to the modulation of force during length oscillation;
however, the depression of force during shortening cannot be accounted
for by cross-bridge properties, shortening-induced cross-bridge
deactivation, or active relaxation. We conclude that the depression of
contractility may be a function of the plasticity of the cellular
organization of contractile filaments, which enables contractile
element length to be reset in relation to smooth muscle cell length as
a result of smooth muscle stretch.
tracheal smooth muscle; airway reactivity; contractile mechanisms; tidal breathing
This article has been cited by other articles:
|
|
 |
|
  M. Baroffio, G. Barisione, E. Crimi, and V. Brusasco Noninflammatory mechanisms of airway hyper-responsiveness in bronchial asthma: an overview Therapeutic Advances in Respiratory Disease, August 1, 2009; 3(4): 163 - 174. [Abstract] [PDF]
|
|
|
|
 |
|
 T. K. Ansell, P. K. McFawn, P. B. Noble, A. R. West, L. Fernandes, and H. W. Mitchell Potent bronchodilation and reduced stiffness by relaxant stimuli under dynamic conditions Eur. Respir. J., April 1, 2009; 33(4): 844 - 851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Zhang and S. J. Gunst Interactions of Airway Smooth Muscle Cells with Their Tissue Matrix: Implications for Contraction Proceedings of the ATS, January 1, 2008; 5(1): 32 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. T. Bates, A. Cojocaru, and L. K. A. Lundblad Bronchodilatory effect of deep inspiration on the dynamics of bronchoconstriction in mice J Appl Physiol, November 1, 2007; 103(5): 1696 - 1705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Noble, P. K. McFawn, and H. W. Mitchell Responsiveness of the isolated airway during simulated deep inspirations: effect of airway smooth muscle stiffness and strain J Appl Physiol, September 1, 2007; 103(3): 787 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Winkler and J. G. Venegas Complex airway behavior and paradoxical responses to bronchoprovocation J Appl Physiol, August 1, 2007; 103(2): 655 - 663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. T. Bates and A.-M. Lauzon Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstriction J Appl Physiol, May 1, 2007; 102(5): 1912 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Gil, N. B. Zitouni, E. Azoulay, K. Maghni, and A.-M. Lauzon Smooth muscle myosin isoform expression and LC20 phosphorylation in innate rat airway hyperresponsiveness Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L932 - L940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Torchio, C. Gulotta, C. Ciacco, A. Perboni, M. Guglielmo, F. Crosa, M. Zerbini, V. Brusasco, R. E. Hyatt, and R. Pellegrino Effects of chest wall strapping on mechanical response to methacholine in humans J Appl Physiol, August 1, 2006; 101(2): 430 - 438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. An, B. Fabry, X. Trepat, N. Wang, and J. J. Fredberg Do Biophysical Properties of the Airway Smooth Muscle in Culture Predict Airway Hyperresponsiveness? Am. J. Respir. Cell Mol. Biol., July 1, 2006; 35(1): 55 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, P. Chitano, and T. M. Murphy Maturation of guinea pig tracheal strip stiffness Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L902 - L908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Lambert and T. A. Wilson Smooth muscle dynamics and maximal expiratory flow in asthma J Appl Physiol, November 1, 2005; 99(5): 1885 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. T. Bates and A.-M. Lauzon Modeling the oscillation dynamics of activated airway smooth muscle strips Am J Physiol Lung Cell Mol Physiol, November 1, 2005; 289(5): L849 - L855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xue, L. Zhang, R. Ramchandani, Y. Liu, V. B. Antony, S. J. Gunst, and R. S. Tepper Respiratory system responsiveness in rabbits in vivo is reduced by prolonged continuous positive airway pressure J Appl Physiol, August 1, 2005; 99(2): 677 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Tepper, R. Ramchandani, E. Argay, L. Zhang, Z. Xue, Y. Liu, and S. J. Gunst Chronic strain alters the passive and contractile properties of rabbit airways J Appl Physiol, May 1, 2005; 98(5): 1949 - 1954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Salerno, R. Pellegrino, G. Trocchio, A. Spanevello, V. Brusasco, and E. Crimi Attenuation of induced bronchoconstriction in healthy subjects: effects of breathing depth J Appl Physiol, March 1, 2005; 98(3): 817 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Bai, J. H. T. Bates, V. Brusasco, B. Camoretti-Mercado, P. Chitano, L. H. Deng, M. Dowell, B. Fabry, L. E. Ford, J. J. Fredberg, et al. On the terminology for describing the length-force relationship and its changes in airway smooth muscle J Appl Physiol, December 1, 2004; 97(6): 2029 - 2034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Khangure, P. B. Noble, A. Sharma, P. Y. Chia, P. K. McFawn, and H. W. Mitchell Cyclical elongation regulates contractile responses of isolated airways J Appl Physiol, September 1, 2004; 97(3): 913 - 919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Noble, P. K. McFawn, and H. W. Mitchell Intraluminal pressure oscillation enhances subsequent airway contraction in isolated bronchial segments J Appl Physiol, March 1, 2004; 96(3): 1161 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Meiss and R. M. Pidaparti Mechanical state of airway smooth muscle at very short lengths J Appl Physiol, February 1, 2004; 96(2): 655 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Brusasco and R. Pellegrino Invited Review: Complexity of factors modulating airway narrowing in vivo: relevance to assessment of airway hyperresponsiveness J Appl Physiol, September 1, 2003; 95(3): 1305 - 1313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Brown and W. Mitzner Invited Review: Understanding airway pathophysiology with computed tomograpy J Appl Physiol, August 1, 2003; 95(2): 854 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.A. McClean, M.J. Matheson, K. McKay, P.R.A. Johnson, A-C. Rynell, A.J. Ammit, J.L. Black, and N. Berend Low lung volume alters contractile properties of airway smooth muscle in sheep Eur. Respir. J., July 1, 2003; 22(1): 50 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. McParland, P. T. Macklem, and P. D. Pare Airway wall remodeling: friend or foe? J Appl Physiol, July 1, 2003; 95(1): 426 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Corsico, M. Milanese, S. Baraldo, G. L. Casoni, A. Papi, A. M. Riccio, I. Cerveri, M. Saetta, and V. Brusasco Small airway morphology and lung function in the transition from normality to chronic airway obstruction J Appl Physiol, July 1, 2003; 95(1): 441 - 447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Anafi, K. C. Beck, and T. A. Wilson Impedance, gas mixing, and bimodal ventilation in constricted lungs J Appl Physiol, March 1, 2003; 94(3): 1003 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Fontana, T. Pantaleo, F. Lavorini, F. Bongianni, M. Mannelli, P. D. Bridge, and M. Pistolesi Handgrip-induced airway dilation in asthmatic patients with bronchoconstriction induced by MCh inhalation J Appl Physiol, November 1, 2002; 93(5): 1723 - 1730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Lambert, R. Ramchandani, X. Shen, S. J. Gunst, and R. S. Tepper Computational model of airway narrowing: mature vs. immature rabbit J Appl Physiol, August 1, 2002; 93(2): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Anafi and T. A. Wilson Empirical model for dynamic force-length behavior of airway smooth muscle J Appl Physiol, February 1, 2002; 92(2): 455 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Latourelle, B. Fabry, and J. J. Fredberg Dynamic equilibration of airway smooth muscle contraction during physiological loading J Appl Physiol, February 1, 2002; 92(2): 771 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Gunst, X. Shen, R. Ramchandani, and R. S. Tepper Bronchoprotective and bronchodilatory effects of deep inspiration in rabbits subjected to bronchial challenge J Appl Physiol, December 1, 2001; 91(6): 2511 - 2516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Brown and W. Mitzner Airway response to deep inspiration: role of inflation pressure J Appl Physiol, December 1, 2001; 91(6): 2574 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Brown and W. Mitzner Effects of tidal volume stretch on airway constriction in vivo J Appl Physiol, November 1, 2001; 91(5): 1995 - 1998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Anafi and T. A. Wilson Airway stability and heterogeneity in the constricted lung J Appl Physiol, September 1, 2001; 91(3): 1185 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Tang and S. J. Gunst Signal Transduction in Smooth Muscle: Selected Contribution: Roles of focal adhesion kinase and paxillin in the mechanosensitive regulation of myosin phosphorylation in smooth muscle J Appl Physiol, September 1, 2001; 91(3): 1452 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Y. Seow and J. J. Fredberg Signal Transduction in Smooth Muscle: Historical perspective on airway smooth muscle: the saga of a frustrated cell J Appl Physiol, August 1, 2001; 91(2): 938 - 952. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Gerthoffer and S. J. Gunst Signal Transduction in Smooth Muscle: Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle J Appl Physiol, August 1, 2001; 91(2): 963 - 972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Oldmixon, K. Carlsson, C. Kuhn III, J. P. Butler, and F. G. Hoppin Jr. {alpha}-Actin: disposition, quantities, and estimated effects on lung recoil and compliance J Appl Physiol, July 1, 2001; 91(1): 459 - 473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Lambert, P. D. Pare, and M. Okazawa Stiffness of peripheral airway folding membrane in rabbits J Appl Physiol, June 1, 2001; 90(6): 2041 - 2047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. R. Shardonofsky, T. M. Officer, A. M. Boriek, and J. R. Rodarte Effects of smooth muscle activation on axial mechanical properties of excised canine bronchi J Appl Physiol, April 1, 2001; 90(4): 1258 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Gunst and M.-F. Wu Plasticity in Skeletal, Cardiac, and Smooth Muscle: Selected Contribution: Plasticity of airway smooth muscle stiffness and extensibility: role of length-adaptive mechanisms J Appl Physiol, February 1, 2001; 90(2): 741 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. BROWN and W. MITZNER Delayed Distension of Contracted Airways with Lung Inflation In Vivo Am. J. Respir. Crit. Care Med., December 1, 2000; 162(6): 2113 - 2116. [Abstract] [Full Text]
|
|
|
|
|
|
T. Kapsali, S. Permutt, B. Laube, N. Scichilone, and A. Togias Potent bronchoprotective effect of deep inspiration and its absence in asthma J Appl Physiol, August 1, 2000; 89(2): 711 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, P. D. Pare, and C. Y. Seow Effects of length oscillation on the subsequent force development in swine tracheal smooth muscle J Appl Physiol, June 1, 2000; 88(6): 2246 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. MITZNER and R. H. BROWN Potential Mechanism of Hyperresponsive Airways Am. J. Respir. Crit. Care Med., May 1, 2000; 161(5): 1619 - 1623. [Abstract] [Full Text]
|
|
|
|
|
|
A. DUGUET, K. BIYAH, E. MINSHALL, R. GOMES, C.-G. WANG, M. TAOUDI-BENCHEKROUN, J. H. T. BATES, and D. H. EIDELMAN Bronchial Responsiveness among Inbred Mouse Strains . Role of Airway Smooth-Muscle Shortening Velocity Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): 839 - 848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. Salerno, N. Shinozuka, J. J. Fredberg, and M. S. Ludwig Tidal volume amplitude affects the degree of induced bronchoconstriction in dogs J Appl Physiol, November 1, 1999; 87(5): 1674 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Brusasco, E. Crimi, G. Barisione, A. Spanevello, J. R. Rodarte, and R. Pellegrino Airway responsiveness to methacholine: effects of deep inhalations and airway inflammation J Appl Physiol, August 1, 1999; 87(2): 567 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. KING, B. J. MOORE, C. Y. SEOW, and P. D. PARÉ Time Course of Increased Airway Narrowing Caused by Inhibition of Deep Inspiration during Methacholine Challenge Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 454 - 457. [Abstract] [Full Text]
|
|
|
|
|
|
J. J. FREDBERG, D. S. INOUYE, S. M. MIJAILOVICH, and J. P. BUTLER Perturbed Equilibrium of Myosin Binding in Airway Smooth Muscle and Its Implications in Bronchospasm Am. J. Respir. Crit. Care Med., March 1, 1999; 159(3): 959 - 967. [Abstract] [Full Text]
|
|
|
|
|
|
R. H. Brown and W. Mitzner The myth of maximal airway responsiveness in vivo J Appl Physiol, December 1, 1998; 85(6): 2012 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Brusasco, E. Crimi, and R. Pellegrino Airway hyperresponsiveness in asthma: not just a matter of airway inflammation Thorax, November 1, 1998; 53(11): 992 - 998. [Full Text]
|
|
|
|
|
|
C. Y. SEOW, R. R. SCHELLENBERG, and P. D. PARE Structural and Functional Changes in the Airway Smooth Muscle of Asthmatic Subjects Am. J. Respir. Crit. Care Med., November 1, 1998; 158(2007): S179 - S186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shen, S. J. Gunst, and R. S. Tepper Effect of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits J Appl Physiol, October 1, 1997; 83(4): 1202 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shen, M. F. Wu, R. S. Tepper, and S. J. Gunst Pharmacological modulation of the mechanical response of airway smooth muscle to length oscillation J Appl Physiol, September 1, 1997; 83(3): 739 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, P. D. Pare, and C. Y. Seow Changes in force-velocity properties of trachealis due to oscillatory strains J Appl Physiol, May 1, 2002; 92(5): 1865 - 1872. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
