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J Appl Physiol 83: 608-614, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 2, pp. 608-614, August 1997
METABOLISM

Oral glucose ingestion increases endurance capacity in normal and diabetic (type I) humans

P. R. Ramires, C. L. M. Forjaz, C. M. C. Strunz, M. E. R. Silva, J. Diament, W. Nicolau, B. Liberman, and C. E. Negrão

Physical Education School, Endocrinology Unit, and Heart Institute, University of São Paulo 05508-900; and Brigadeiro Hospital, São Paulo 01401-901, Brazil

Received 21 June 1996; accepted in final form 4 April 1997.

Ramires, P. R., C. L. M. Forjaz, C. M. C. Strunz, M. E. R. Silva, J. Diament, W. Nicolau, B. Liberman, and C. E. Negrão. Oral glucose ingestion increases endurance capacity in normal and diabetic (type I) humans. J. Appl. Physiol. 83(2): 608-614, 1997.---The effects of an oral glucose administration (1 g/kg) 30 min before exercise on endurance capacity and metabolic responses were studied in 21 type I diabetic patients [insulin-dependent diabetes mellitus (IDDM)] and 23 normal controls (Con). Cycle ergometer exercise (55-60% of maximal O2 uptake) was performed until exhaustion. Glucose administration significantly increased endurance capacity in Con (112 ± 7 vs. 125 ± 6 min, P < 0.05) but only in IDDM patients whose blood glucose decreased during exercise (70.8 ± 8.2 vs. 82.8 ± 9.4 min, P < 0.05). Hyperglycemia was normalized at 15 min of exercise in Con (7.4 ± 0.2 vs. 4.8 ± 0.2 mM) but not in IDDM patients (12.4 ± 0.7 vs. 15.6 ± 0.9 mM). In Con, insulin and C-peptide levels were normalized during exercise. Glucose administration decreased growth hormone levels in both groups. In conclusion, oral glucose ingestion 30 min before exercise increases endurance capacity in Con and in some IDDM patients. In IDDM patients, in contrast with Con, exercise to exhaustion attenuates hyperglycemia but does not bring blood glucose levels to preglucose levels.

exercise; substrates; hormones; insulin-dependent diabetes mellitus

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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