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Departments of Surgery, Physiology, and Pediatrics, Medical College of Wisconsin, Milwaukee 53226; Biomedical Engineering Department Marquette University, Milwaukee 53233; and Zablocki Veterans Affairs Medical Center, Milwaukee, Wisconsin 53295
Received 17 December 1996; accepted in final form 21 April 1997.
Chammas, Joseph H., David. A. Rickaby, Margarita Guarin,
John H. Linehan, Christopher C. Hanger, and Christopher A. Dawson. Flow-induced vasodilation in the ferret lung. J. Appl. Physiol. 83(2): 495-502, 1997.
To examine
the possibility that shear stress may be a pulmonary vasodilator
stimulus, we studied the effect of changing blood flow on the diameters
of small pulmonary arteries in isolated perfused ferret lung lobes. The
arteries studied were in the ~0.3- to 1.3-mm-diameter range, and the
diameters were measured by using microfocal X-ray imaging. The
diameters were measured at two flow rates, 10 and 40 ml/min, with the
intravascular pressure in the measured vessels the same at the two flow
rates as the result of venous pressure adjustment. The response to a change in flow was studied under both normoxic and hypoxic conditions. Hypoxia was used to elevate pulmonary arterial tone to increase the
likelihood of detecting a vasodilator response. Under normoxic conditions, changing flow had little effect on the arterial diameters, but under hypoxic conditions the arteries were consistently larger at
the higher flow than at the lower flow, even though the distending pressure was the same at the two flow rates. The results are consistent with the hypothesis that shear stress is a pulmonary vasodilator stimulus.
shear stress; hypoxic pulmonary vasoconstriction; pulmonary arterial diameters; nitric oxide
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