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J Appl Physiol 83: 444-450, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 2, pp. 444-450, August 1997
EXERCISE AND MUSCLE

Contractile apparatus and sarcoplasmic reticulum function: effects of fatigue, recovery, and elevated Ca2+

Jay H. Williams

Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0430

Received 23 December 1996; accepted in final form 7 April 1997.

Williams, Jay H. Contractile apparatus and sarcoplasmic reticulum function: effects of fatigue, recovery, and elevated Ca2+. J. Appl. Physiol. 83(2): 444-450, 1997.---This investigation tested the notion that fatiguing stimulation induces intrinsic changes in the contractile apparatus and sarcoplasmic reticulum (SR) and that these changes are initiated by elevated intracellular Ca2+ concentration ([Ca2+]i). Immediately after stimulation of frog semitendinosus muscle, contractile apparatus and SR function were measured. Despite a large decline in tetanic force (Po), maximal Ca2+-activated force (Fmax) of the contractile apparatus was not significantly altered. However, Ca2+ sensitivity was increased. In conjunction, the rate constant of Ca2+ uptake by the SR was diminished, and the caffeine sensitivity of Ca2+ release was decreased. During recovery, Po, contractile apparatus, and SR function each returned to near-initial levels. Exposure of skinned fibers to 0.5 µM free Ca2+ for 5 min depressed both Fmax and Ca2+ sensitivity of the contractile apparatus. In addition, caffeine sensitivity of Ca2+ release was diminished. Results suggest that fatigue induces intrinsic alterations in contractile apparatus and SR function. Changes in contractile apparatus function do not appear to be mediated by increased [Ca2+]i. However, a portion of the change in SR Ca2+ release seems to be due to elevated [Ca2+]i.

skeletal muscle; skinned fibers; calcium

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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