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Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Received 23 August 1996; accepted in final form 25 March 1997.
Smith, Francine G., Suzanne Chan, and Saskia N. De Wildt.
Effects of renal denervation on cardiovascular and renal responses
to ACE inhibition in conscious lambs. J. Appl.
Physiol. 83(2): 414-419, 1997.
Cardiovascular and
renal effects of either the angiotensin-converting enzyme inhibitor
captopril or vehicle were measured in chronically instrumented lambs in
the presence (intact; n = 6) and
absence of renal sympathetic nerves (denervated; n = 5) to determine whether there was
an interaction between the renin-angiotensin system and renal
sympathetic nerves early in life. Captopril caused a similar decrease
in mean arterial pressure (P < 0.001) in intact and denervated lambs, predominantly through a decrease
in diastolic pressure. Heart rate was increased from 177 ± 34 to
213 ± 22 (SD) beats/min during captopril compared with vehicle
infusion in intact lambs. In denervated lambs, basal heart rates were
elevated to 218 ± 33 beats/min; there was no further increase in
heart rate during captopril compared with vehicle infusion. Captopril
infusion caused a decrease in renal vascular resistance but only in the
absence of renal nerves. These findings provide evidence to suggest
that early in life there is an interaction between renal sympathetic
nerves and the renin-angiotensin system in regulating renal
hemodynamics and the baroreflex control of the heart.
angiotensin-converting enzyme; renal nerves; newborn; angiotensin II; captopril; blood pressure; baroreflex
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