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J Appl Physiol 83: 407-413, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 2, pp. 407-413, August 1997
SYSTEMIC CIRCULATION AND FLUID BALANCE

Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia

Andrew Haskell, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack

The John B. Pierce Laboratory and Departments of Epidemiology and Public Health and of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519

Received 16 December 1996; accepted in final form 2 April 1997.

Haskell, Andrew, Ethan R. Nadel, Nina S. Stachenfeld, Kei Nagashima, and Gary W. Mack. Transcapillary escape rate of albumin in humans during exercise-induced hypervolemia. J. Appl. Physiol. 83(2): 407-413, 1997.---To test the hypotheses that plasma volume (PV) expansion 24 h after intense exercise is associated with reduced transcapillary escape rate of albumin (TERalb) and that local changes in transcapillary forces in the previously active tissues favor retention of protein in the vascular space, we measured PV, TERalb, plasma colloid osmotic pressure (COPp), interstitial fluid hydrostatic pressure (Pi), and colloid osmotic pressure in leg muscle and skin and capillary filtration coefficient (CFC) in the arm and leg in seven men and women before and 24 h after intense upright cycle ergometer exercise. Exercise expanded PV by 6.4% at 24 h (43.9 ± 0.8 to 46.8 ± 1.2 ml/kg, P < 0.05) and decreased total protein concentration (6.5 ± 0.1 to 6.3 ± 0.1 g/dl, P < 0.05) and COPp (26.1 ± 0.8 to 24.3 ± 0.9 mmHg, P < 0.05), although plasma albumin concentration was unchanged. TERalb tended to decline (8.4 ± 0.5 to 6.5 ± 0.7%/h, P = 0.11) and was correlated with the increase in PV (r = -0.69, P < 0.05). CFC increased in the leg (3.2 ± 0.2 to 4.3 ± 0.5 µl · 100 g-1 · min-1 · mmHg-1, P < 0.05), and Pi showed a trend to increase in the leg muscle (2.8 ± 0.7 to 3.8 ± 0.3 mmHg, P = 0.08). These data demonstrate that TERalb is associated with PV regulation and that local transcapillary forces in the leg muscle may favor retention of albumin in the vascular space after exercise.

capillary filtration coefficient; Evans blue dye; interstitial fluid colloid osmotic pressure; interstitial fluid hydrostatic pressure; plasma volume

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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