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J Appl Physiol 83: 391-397, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 2, pp. 391-397, August 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Cerebellar modulation of cough motor pattern in cats

Fadi Xu, Donald T. Frazier, Zhong Zhang, David M. Baekey, and Roger Shannon

Department of Physiology, University of Kentucky, Lexington, Kentucky 40536; and Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa, Florida 33612

Received 29 January 1997; accepted in final form 28 March 1997.

Xu, Fadi, Donald T. Frazier, Zhong Zhang, David M. Baekey, and Roger Shannon. Cerebellar modulation of cough motor pattern in cats. J. Appl. Physiol. 83(2): 391-397, 1997.---The cerebellum modulates respiratory muscle activity in part via its influence on the central respiratory pattern generator. Because coughing requires well-coordinated respiratory muscle activity, studies were conducted to determine whether the cerebellum influences the centrally generated cough motor pattern. Integrated phrenic and lumbar efferent neurograms (<LIM><OP>∫</OP></LIM>PN and <LIM><OP>∫</OP></LIM>LN, respectively) were monitored in decerebrated, paralyzed, and ventilated cats. Mechanical probing of the intrathoracic trachea was used to evoke fictive coughs; i.e., large increases in <LIM><OP>∫</OP></LIM>PN and <LIM><OP>∫</OP></LIM>LN amplitudes. Cerebellectomy resulted in a decrease in the number of coughs per trial (cough frequency) and <LIM><OP>∫</OP></LIM>LN peak amplitudes without any consistent change in <LIM><OP>∫</OP></LIM>PN peak amplitudes. Cerebellar nuclei [the rostral interposed nucleus (INr) and the rostral fastigial nucleus (FNr)] known to be involved in respiratory control were ablated to determine their potential role in the cough response. Control (eupneic) respiratory frequency was not affected by cerebellectomy or INr/FNr lesions. Cough frequency was depressed by lesion of the INr but not by ablation of the FNr. No significant changes in <LIM><OP>∫</OP></LIM>PN and <LIM><OP>∫</OP></LIM>LN amplitudes were observed after lesion of either the INr or FNr. These results suggest that the cerebellum, specifically the INr, is involved in modulation of the frequency of centrally generated coughing.

fastigial nucleus; interposed nucleus; lumbar nerve motor activity; respiratory control; tracheal probing; thermal lesions

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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