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J Appl Physiol 83: 82-88, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 1, pp. 82-88, July 1997
CONTROL OF BREATHING, CIRCULATION, AND TEMPERATURE

Ventilatory response to helium-oxygen breathing during exercise: effect of airway anesthesia

Bharath S. Krishnan, Ron E. Clemens, Trevor A. Zintel, Martin J. Stockwell, and Charles G. Gallagher

Division of Respiratory Medicine, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W8

Received 21 August 1996; accepted in final form 14 March 1997.

Krishnan, Bharath S., Ron E. Clemens, Trevor A. Zintel, Martin J. Stockwell, and Charles G. Gallagher. Ventilatory response to helium-oxygen breathing during exercise: effect of airway anesthesia. J. Appl. Physiol. 83(1): 82-88, 1997.---The substitution of a normoxic helium mixture (HeO2) for room air (Air) during exercise results in a sustained hyperventilation, which is present even in the first breath. We hypothesized that this response is dependent on intact airway afferents; if so, airway anesthesia (Anesthesia) should affect this response. Anesthesia was administered to the upper airways by topical application and to lower central airways by aerosol inhalation and was confirmed to be effective for over 15 min. Subjects performed constant work-rate exercise (CWE) at 69 ± 2 (SE) % maximal work rate on a cycle ergometer on three separate days: twice after saline inhalation (days 1 and 3) and once after Anesthesia (day 2). CWE commenced after a brief warm-up, with subjects breathing Air for the first 5 min (Air-1), HeO2 for the next 3 min, and Air again until the end of CWE (Air-2). The resistance of the breathing circuit was matched for Air and HeO2. Breathing HeO2 resulted in a small but significant increase in minute ventilation (VI) and decrease in alveolar PCO2 in both the Saline (average of 2 saline tests; not significant) and Anesthesia tests. Although Anesthesia had no effect on the sustained hyperventilatory response to HeO2 breathing, the VI transients within the first six breaths of HeO2 were significantly attenuated with Anesthesia. We conclude that the VI response to HeO2 is not simply due to a reduction in external tubing resistance and that, in humans, airway afferents mediate the transient but not the sustained hyperventilatory response to HeO2 breathing during exercise.

heliox hyperventilation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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