Journal of Applied Physiology Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 67-73, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Larkin, L. M.
Right arrow Articles by Halter, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Larkin, L. M.
Right arrow Articles by Halter, J. B.

Journal of Applied Physiology
Vol. 83, No. 1, pp. 67-73, July 1997
EXERCISE AND MUSCLE

Functional deficits in medial gastrocnemius grafts in rats: relation to muscle metabolism and beta -AR regulation

Lisa M. Larkin1,2, John A. Faulkner2, Richard T. Hinkle2, Cheryl A. Hassett2, Mark A. Supiano1,2,3, and Jeffrey B. Halter1,2,3

1 Division of Geriatric Medicine, Department of Internal Medicine, and 2 Institute of Gerontology, University of Michigan, Ann Arbor 48105; and 3 Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Medical Center, Ann Arbor, Michigan 48109

Received 11 October 1996; accepted in final form 11 March 1997.

Larkin, Lisa M., John A. Faulkner, Richard T. Hinkle, Cheryl A. Hassett, Mark A. Supiano, and Jeffrey B. Halter. Functional deficits in medial gastrocnemius grafts in rats: relation to muscle metabolism and beta -AR regulation. J. Appl. Physiol. 83(1): 67-73, 1997.---This study tested the hypothesis that alterations in the metabolic integrity of grafted muscle contribute to its diminished ability to sustain power. Compared with control muscles, muscles studied 120 days after the grafting procedure had lower specific force and sustained power. The sustained power protocol resulted in a depletion of muscle glycogen in control (83%) and grafted (85%) animals. Grafts had lower pre- and poststimulation glycogen, diminished citrate synthase activity, and greater hexokinase activity. No differences were observed in phosphofructokinase activity, glucose transporter GLUT-4 content, fiber type, beta -adrenergic-receptor (beta -AR) density, or binding affinity. Isoproterenol-stimulated adenylyl cyclase activity was lower in grafted vs. control muscle, suggesting an uncoupling of the beta -AR-effector complex. Thus the diminished ability of the grafted muscle to sustain power may be explained, in part, by a decrease in energy available from glycogen stores and/or a decrease in oxidative capacity.

sustained power; hexokinase; citrate synthase; glycogen; GLUT-4; fiber type; beta -adrenergic-receptor function

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. V. Brooks, A. Vasilaki, L. M. Larkin, A. McArdle, and M. J. Jackson
Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor {kappa}B activation
J. Physiol., August 15, 2008; 586(16): 3979 - 3990.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. M. Larkin, W. M. Kuzon Jr., and J. B. Halter
Synergist muscle ablation and recovery from nerve-repair grafting: contractile and metabolic function
J Appl Physiol, October 1, 2000; 89(4): 1469 - 1476.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online