Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 83: 280-290, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 1, pp. 280-290, July 1997
EXERCISE AND MUSCLE

Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers

Roland R. Roy, Robert J. Talmadge, Kenneth Fox, Michael Lee, Aki Ishihara, and V. Reggie Edgerton

Department of Physiological Science and Brain Research Institute, University of California, Los Angeles, California 90095-1761

Received 17 July 1996; accepted in final form 13 March 1997.

Roy, Roland R., Robert J. Talmadge, Kenneth Fox, Michael Lee, Aki Ishihara, and V. Reggie Edgerton. Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers. J. Appl. Physiol. 83(1): 280-290, 1997.---The effects of 1 and 10 wk of functional overload (FO) of the rat plantaris with (FOTr) and without daily endurance treadmill training on its myosin heavy chain (MHC) composition were studied. After 1 and 10 wk of FO, plantaris mass was 22 and 56% greater in FO and 37 and 94% greater, respectively, in FOTr rats compared with age-matched controls. At 1 wk, pure type I and pure type IIa MHC fibers were hypertrophied in FO (39 and 44%) and FOTr (70 and 87%) rats. By 10 wk all fiber types comprising >5% of the fibers sampled showed a hypertrophic response in both FO groups. One week of FO increased the percentage of hybrid (containing both type I and type IIa MHC) fibers and of fibers containing embryonic MHC. By 10 wk, the percentage of pure type I MHC fibers was ~40% in both FO groups compared with 15% in controls, and the percentage of fibers containing embryonic MHC was similar to that in controls. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed an increase in type I MHC and a decrease in type IIb MHC in both FO groups at 10 wk, whereas little change was observed at 1 wk. These data are consistent with hypertrophy and transformation from faster to slower MHC isoforms in chronically overloaded muscles. The additional overload imposed by daily endurance treadmill training employed in this study (1.6 km/day; 10% incline) results in a larger hypertrophic response but appears to have a minimal effect on the MHC adaptations.

immunohistochemistry; gel electrophoresis; hypertrophy; fiber type conversion; fiber size

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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