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J Appl Physiol 83: 247-252, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 1, pp. 247-252, July 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung

David R. Jones, Randy M. Becker, Steve C. Hoffmann, John J. Lemasters, and Thomas M. Egan

Division of Cardiothoracic Surgery, Department of Surgery, and Department of Cell Biology and Anatomy, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599

Received 23 December 1996; accepted in final form 14 March 1997.

Jones, David R., Randy M. Becker, Steve C. Hoffmann, John J. Lemasters, and Thomas M. Egan. When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung. J. Appl. Physiol. 83(1): 247-252, 1997.---Lungs harvested from cadaveric circulation-arrested donors may increase the donor pool for lung transplantation. To determine the degree and time course of ischemia-reperfusion injury, we evaluated the effect of O2 ventilation on capillary permeability [capillary filtration coefficient (Kfc)], cell viability, and total adenine nucleotide (TAN) levels in in situ circulation-arrested rat lungs. Kfc increased with increasing postmortem ischemic time (r = 0.88). Lungs ventilated with O2 1 h postmortem had similar Kfc and wet-to-dry ratios as controls. Nonventilated lungs had threefold (P < 0.05) and sevenfold (P < 0.0001) increases in Kfc at 30 and 60 min postmortem compared with controls. Cell viability decreased in all groups except for 30-min postmortem O2-ventilated lungs. TAN levels decreased with increasing ischemic time, particularly in nonventilated lungs. Loss of adenine nucleotides correlated with increasing Kfc values (r = 0.76). This study indicates that lungs retrieved 1 h postmortem may have normal Kfc with preharvest O2 ventilation. The relationship between Kfc and TAN suggests that vascular permeability may be related to lung TAN levels.

capillary filtration coefficient; cadaveric lung transplantation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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