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J Appl Physiol 83: 213-218, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 1, pp. 213-218, July 1997
PULMONARY CIRCULATION AND LUNG FLUID BALANCE

Postnatal lung function and protein permeability after fetal or maternal corticosteroids in preterm lambs

Celso M. Rebello, Machiko Ikegami, M. Gore Ervin, Daniel H. Polk, and Alan H. Jobe

Perinatal Research Laboratories, Harbor-UCLA Medical Center, University of California, Los Angeles, School of Medicine, Torrance, California 90502

Received 10 September 1996; accepted in final form 12 March 1997.

Rebello, Celso M., Machiko Ikegami, M. Gore Ervin, Daniel H. Polk, and Alan H. Jobe. Postnatal lung function and protein permeability after fetal or maternal corticosteroids in preterm lambs. J. Appl. Physiol. 83(1): 213-218, 1997.---We evaluated postnatal lung function and intravascular albumin loss to tissues of 123-days-gestation preterm surfactant-treated and ventilated lambs 15 h after direct fetal (n = 8) or maternal (n = 9) betamethasone treatment or saline placebo (n = 9). The betamethasone-treated groups had similar increases in dynamic compliances, ventilatory efficiency indexes, and lung volumes relative to controls (P < 0.05). The losses of 125I-labeled albumin from blood, a marker of intravascular integrity, and the recoveries of 125I-albumin in muscle and brain were similar for control and betamethasone-exposed lambs. Betamethasone-treated lambs had lower recoveries of 125I-albumin in lung tissues and in alveolar washes than did controls (P < 0.01). Although blood pressures were higher for the treated groups (P < 0.05), all groups had similar blood volumes, cardiac outputs, and organ blood flows. Maternal or fetal treatment with betamethasone 15 h before preterm delivery equivalently improved postnatal lung function, reduced albumin recoveries in lungs, and increased blood pressures. However, prenatal betamethasone had no effects on the systemic intravascular losses of albumin or did not change blood volumes.

respiratory distress syndrome; edema; fetal therapy; lung maturation

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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