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Department of Physiology, Faculty of Medicine, University of Kuopio, 70211 Kuopio, Finland
Received 15 October 1996; accepted in final form 6 March 1997.
Sen, Chandan K., Mustafa Atalay, Jyrki Ågren,
David E. Laaksonen, Sashwati Roy, and Osmo Hänninen. Fish
oil and vitamin E supplementation in oxidative stress at rest and after
physical exercise. J. Appl. Physiol.
83(1): 189-195, 1997.
Fish oil supplementation and physical
exercise may induce oxidative stress. We tested the effects of 8 wk of
-tocopherol (vitamin E) and fish oil (FO) supplementation on resting and exercise-induced oxidative stress. Rats
(n = 80) were divided into groups
supplemented with FO, FO and vitamin E (FOVE), soy oil (SO), and SO and
vitamin E (SOVE), and for FOVE and SOVE they were divided
into corresponding exercise groups (FOVE-Ex and SOVE-Ex). Lipid
peroxidation [thiobarbituric acid-reacting substances
(TBARS)] was 33% higher in FO compared with SO in the liver, but
oxidative protein damage (carbonyl levels) remained similar in both
liver and red gastrocnemius muscle (RG). Vitamin E supplementation,
compared with FO and SO, markedly decreased liver and RG TBARS, but
liver TBARS remained 32% higher in FOVE vs. SOVE. Vitamin E also
markedly decreased liver and RG protein carbonyl levels, although
levels in FOVE and SOVE were similar. Exercise increased liver and RG
TBARS and RG protein carbonyl levels markedly, with similar levels in
FOVE-Ex and SOVE-Ex. FO increased lipid peroxidation but not protein
oxidation in a tissue-specific manner. Vitamin E markedly decreased
lipid peroxidation and protein oxidation in both FOVE and SOVE,
although liver lipid peroxidation remained higher in FOVE. Despite
higher levels of hepatic lipid peroxidation at rest in FOVE compared
with SOVE, liver appeared to be relatively less susceptible to
exercise-induced oxidative stress in FOVE.
polyunsaturated fatty acids; 
-oxidation; lipid peroxidation; protein oxidation; antioxidant
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