Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 83: 172-178, 1997;
8750-7587/97 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bloomfield, S. A.
Right arrow Articles by Weisbrode, S. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bloomfield, S. A.
Right arrow Articles by Weisbrode, S. E.

Journal of Applied Physiology
Vol. 83, No. 1, pp. 172-178, July 1997
METABOLISM

Effects of vigorous exercise training and beta -agonist administration on bone response to hindlimb suspension

Susan A. Bloomfield, Beverly E. Girten, and Steven E. Weisbrode

School of Health, Physical Education, and Recreation and Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210-1290

Received 10 July 1996; accepted in final form 12 March 1997.

Bloomfield, Susan A., Beverly E. Girten, and Steven E. Weisbrode. Effects of vigorous exercise training and beta -agonist administration on bone response to hindlimb suspension. J. Appl. Physiol. 83(1): 172-178, 1997.---The effectiveness of dobutamine (Dob) in preventing bone loss during 14 days of hindlimb suspension (Sus) was tested in exercise-trained (Ex; n = 25) and sedentary (Sed; n = 22) rats (age 155 days). One-half of each group was given Dob (2 mg · kg-1 · day-1) or saline (Sal). Histomorphometric measurements at midfemur revealed a 17% smaller cortical bone area (CBA) and a 32% lower periosteal mineral apposition rate (MAR) in suspended vs. nonsuspended Sed/Sal rats. Dob abolished this decline in CBA in Sed/Sus rats, probably via an attenuation of the decrease in periosteal MAR; similar but nonsignificant effects on cross-sectional moment of inertia were observed. Nonsuspended Ex rats had no change in bone CBA when CBA is indexed to body weight. Sus appeared to uncouple the relationship between soleus weight and CBA. Dob attenuated the 43% decline in soleus weight after Sus in Ex but not in Sed rats. In summary, vigorous Ex before Sus does not affect loss of bone mass due to unloading; Dob effectively maintains CBA in Sed rats subjected to suspension.

dobutamine; rat; unloading; histomorphometry; cortical bone

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. Baek, A. A. Barlow, M. R. Allen, and S. A. Bloomfield
Food restriction and simulated microgravity: effects on bone and serum leptin
J Appl Physiol, April 1, 2008; 104(4): 1086 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
T. Foutz, A. Ratterman, and J. Halper
Effects of Immobilization on the Biomechanical Properties of the Broiler Tibia and Gastrocnemius Tendon
Poult. Sci., May 1, 2007; 86(5): 931 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
B Le Panse, A Arlettaz, H Portier, A-M Lecoq, J De Ceaurriz, and K Collomp
Short term salbutamol ingestion and supramaximal exercise in healthy women
Br. J. Sports Med., July 1, 2006; 40(7): 627 - 631.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Cavalie, G. Lac, P. Lebecque, B. Chanteranne, M.-J. Davicco, and J.-P. Barlet
Influence of clenbuterol on bone metabolism in exercised or sedentary rats
J Appl Physiol, December 1, 2002; 93(6): 2034 - 2037.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. N. Colleran, M. K. Wilkerson, S. A. Bloomfield, L. J. Suva, R. T. Turner, and M. D. Delp
Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling
J Appl Physiol, September 1, 2000; 89(3): 1046 - 1054.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online