Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 83: 140-147, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 83, No. 1, pp. 140-147, July 1997
GAS EXCHANGE, MECHANICS, AND AIRWAYS

Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness

Rodney K. Lambert and Peter D. Paré

Department of Physics, Massey University, Palmerston North, New Zealand 5320; and Respiratory Health Network of Centres of Excellence, University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6

Received 18 July 1996; accepted in final form 6 March 1997.

Lambert, Rodney K., and Peter D. Paré. Lung parenchymal shear modulus, airway wall remodeling, and bronchial hyperresponsiveness. J. Appl. Physiol. 83(1): 140-147, 1997.---When airways narrow, either through the action of smooth muscle shortening or during forced expiration, the lung parenchyma is locally distorted and provides an increased peribronchial stress that resists the narrowing. Although this interdependence has been well studied, the quantitative significance of airway remodeling to interdependence has not been elucidated. We have used an improved computational model of the bronchial response to smooth muscle agonists to investigate the relationships between airway narrowing (as indicated by airway resistance), parenchymal shear modulus, adventitial thickening, and inner wall thickening at lung recoil pressures of 4, 5, and 8 cmH2O. We have found that, at low recoil pressures, decreases in parenchymal shear modulus have a significant effect that is comparable to that of moderate thickening of the airway wall. At higher lung recoil pressures, the effect is negligible.

dose-response; airway mechanics

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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