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Prince of Wales Medical Research Institute and Department of Respiratory Medicine, Prince of Wales Hospital, University of New South Wales, Sydney, New South Wales, Australia 2031
Received 2 January 1996; accepted in final form 11 February 1997.
McKenzie, D. K., G. M. Allen, J. E. Butler, and S. C. Gandevia. Task failure with lack of diaphragm fatigue during inspiratory resistive loading in human subjects. J. Appl. Physiol. 82(6): 2011-2019, 1997.
Task
failure during inspiratory resistive loading is thought to be
accompanied by substantial peripheral fatigue of the inspiratory
muscles. Six healthy subjects performed eight resistive breathing
trials with loads of 35, 50, 75 and 90% of maximal inspiratory
pressure (MIP) with and without supplemental oxygen. MIP measured
before, after, and at every minute during the trial increased slightly
during the trials, even when corrected for lung volume (e.g., for 24 trials breathing air, 12.5% increase, P < 0.05). In some trials, task
failure occurred before 20 min (end point of trial), and in these
trials there was an increase in end-tidal
PCO2
(P < 0.01), despite the absence of peripheral muscle fatigue. In four subjects (6 trials with task failure), there was no decline in twitch amplitude with bilateral phrenic stimulation or in voluntary activation of the diaphragm, even
though end-tidal PCO2 rose by 1.6 ± 0.9%. These results suggest that hypoventilation,
CO2 retention, and ultimate task
failure during resistive breathing are not simply dependent on impaired
force-generating capacity of the diaphragm or impaired voluntary
activation of the diaphragm.
muscle fatigue; respiratory control; phrenic nerve stimulation
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