Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol 82: 1979-1988, 1997;
8750-7587/97 $5.00
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Journal of Applied Physiology
Vol. 82, No. 6, pp. 1979-1988, June 1997
METABOLISM

Marked differences in functioning of the hypothalamicpituitary-adrenal axis between groups of men

John S. Petrides1, Philip W. Gold4, Gregory P. Mueller2, Anita Singh1, Costas Stratakis3, George P. Chrousos3, and Patricia A. Deuster1

1 Department of Military and Emergency Medicine and 2 Department of Physiology, Uniformed Services University of the Health Sciences, and 3 Developmental Endocrinology Branch, National Institute of Child Health and Development, and 4 Clinical Neuroendocrinology Branch, National Institute of Mental Health, Bethesda, Maryland 20814

Received 10 June 1996; accepted in final form 19 February 1997.

Petrides, John S., Philip W. Gold, Gregory P. Mueller, Anita Singh, Costas Stratakis, George P. Chrousos, and Patricia A. Deuster. Marked differences in functioning of the hypothalamic-pituitary-adrenal axis between groups of men. J. Appl. Physiol. 82(6): 1979-1988, 1997.---To compare profiles of hypothalamic-pituitary-adrenal (HPA) responsiveness, healthy, moderately trained men (n = 15) were classified as high (n = 7) or low responders (n = 8) on the basis of plasma adrenocorticotropic hormone (ACTH) responses to strenuous treadmill exercise 4 h after 4 mg of dexamethasone (Dex). These groups were then evaluated to compare 1) HPA and growth hormone responses to exercise at 90% maximal oxygen uptake 4 h after placebo, Dex (4 mg), and hydrocortisone (100 mg); 2) pituitary-adrenal responses to infusion of arginine vasopressin (AVP); 3) plasma cortisol after a Dex suppression test (1 mg); and 4) behavioral characteristics. In comparison to low responders, high responders exhibited significantly 1) higher plasma ACTH responses to exercise after placebo and Dex; 2) higher plasma AVP secretion with exercise after placebo and marked Dex- and hydrocortisone-induced enhancement of exercise-induced AVP secretion; 3) lower Dex-induced increases in basal and stimulated growth hormone secretion; 4) higher plasma ACTH responses to infusion of AVP; and 5) a trend (P = 0.09) for higher trait anxiety ratings. Similar suppression of plasma cortisol was noted after 1 mg Dex. We conclude that subgroups of healthy male volunteers exhibit unique profiles of HPA responsiveness. We also believe that glucocorticoid pretreatment combined with strenuous exercise allows functional HPA responsiveness to be distinguished between subgroups of healthy controls and may be useful in the determination of susceptibility to disorders characterized by hyper- and hypo-HPA activation.

stress; adrenocorticotropic hormone; cortisol; dexamethasone and hydrocortisone

0161-7567/97 $5.00 Copyright © 1997 the American Physiological Society




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